Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | NOS3 | P29474 | 1/20 | 0.31 |
| ▸ | NOS1 | P29475 | 1/20 | 0.31 |
| ▸ | NOS2 | P35228 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7329723 | 0.77 | LMNA (0.37) | LMNAKDM4EALDH1A1 | |
| SCHEMBL11836648 | 0.71 | LMNA (0.58) | LMNAKDM4EALDH1A1NOS3NOS1 | |
| SCHEMBL34472783 | 0.71 | LMNA (0.58) | LMNAKDM4EALDH1A1NOS3NOS1 | |
| SCHEMBL27327809 | 0.66 | ADH1B (0.31) | — | |
| SCHEMBL7267205 | 0.66 | LMNA (0.46) | LMNAKDM4EALDH1A1NOS3NOS1 | |
| SCHEMBL2643813 | 0.65 | LMNA (0.50) | LMNAKDM4EALDH1A1NOS3NOS1 | |
| SCHEMBL8020079 | 0.60 | MAPK1 (0.34) | LMNAKDM4EALDH1A1 | |
| SCHEMBL26492489 | 0.60 | KDM4E (0.32) | LMNAKDM4EALDH1A1 | |
| SCHEMBL6038800 | 0.60 | LMNA (0.52) | LMNAKDM4EALDH1A1NOS1 | |
| SCHEMBL7267204 | 0.60 | LMNA (0.40) | LMNAKDM4EALDH1A1NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5215966-A | For treatment of hypertension, hyperaldosteronism and cardiac insufficiency | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1993-06-01 | — | — | US | disclosed |
| EP-0327877-A2 | Peptide-renininhibitors | MERCK PATENT GmbH (DE) | 1989-08-16 | — | — | EP | disclosed |
| EP-0272444-A2 | Renin-inhibiting peptides | MERCK PATENT GmbH (DE) | 1988-06-29 | — | — | EP | disclosed |