Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | GRK2 | P25098 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9558788 | 0.82 | KMT2A (0.64) | KMT2ARXFP1ALDH1A1MAPTMEN1 | |
| SCHEMBL9558728 | 0.80 | KMT2A (0.61) | KMT2ARXFP1ALDH1A1MAPTMEN1 | |
| SCHEMBL9559096 | 0.77 | LMNA (0.51) | KMT2AALDH1A1MAPTMEN1POLB | |
| SCHEMBL9837989 | 0.76 | HDAC3 (0.46) | KMT2ARXFP1ALDH1A1MAPTMEN1 | |
| SCHEMBL9558402 | 0.75 | MAPT (0.50) | KMT2ARXFP1ALDH1A1MAPTMEN1 | |
| SCHEMBL7822207 | 0.68 | HDAC3 (0.65) | KMT2AALDH1A1MAPTMEN1POLB | |
| SCHEMBL7701586 | 0.67 | THRB (0.62) | KMT2ARXFP1MAPTMEN1TP53 | |
| SCHEMBL10307779 | 0.67 | ALDH1A1 (0.74) | KMT2AALDH1A1MAPTMEN1POLB | |
| SCHEMBL2760768 | 0.66 | ALDH1A1 (0.51) | KMT2AALDH1A1MAPTMEN1GAA | |
| SCHEMBL9840092 | 0.66 | TDP1 (0.50) | KMT2AALDH1A1MAPTMEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5225444-A | Antiinflammatory agents or antiallergens | G. D. SEARLE & CO. (US) | 1993-07-06 | — | — | US | disclosed |
| US-5071876-A | Antiinflammatory agent; antiallergen; skin disorders; asthma; enzyme inhibitors of 5-lipogenase | G. D. SEARLE & CO. (US) | 1991-12-10 | — | — | US | disclosed |
| EP-0190682-A2 | Novel disubstituted 4-hydroxyphenylthio anilides | G.D. Searle & Co. (US) | 1986-08-13 | — | — | EP | disclosed |