Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 1/20 | 0.41 |
| ▸ | MIF | P14174 | 2/20 | 0.41 |
| ▸ | ACHE | P22303 | 3/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | STAT3 | P40763 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.31 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.31 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13799939 | 1.00 | CHRNA7 (0.41) | CHRNA7MIFACHEALOX5TDP1 | |
| SCHEMBL955932 | 1.00 | CHRNA7 (0.41) | CHRNA7MIFACHEALOX5TDP1 | |
| SCHEMBL443529 | 0.91 | MIF (0.46) | MIF | |
| SCHEMBL22279374 | 0.84 | MIF (0.42) | MIFGAALMNAALDH1A1 | |
| SCHEMBL21304587 | 0.84 | MIF (0.42) | MIFGAALMNAALDH1A1 | |
| SCHEMBL13953683 | 0.83 | MIF (0.41) | MIF | |
| SCHEMBL1755331 | 0.83 | MIF (0.41) | MIF | |
| SCHEMBL17027583 | 0.81 | ADRB2 (0.45) | MIFTDP1HSD11B1HPGDMEN1 | |
| SCHEMBL16034537 | 0.81 | MIF (0.39) | MIFTDP1HSD11B1LMNAALDH1A1 | |
| SCHEMBL958908 | 0.81 | MIF (0.39) | MIFALOX5HSD11B1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102224139-B | 4- (azacycloalkyl) benzene-1, 3-diol compounds as tyrosinase inhibitors, process for their preparation and their use in human medicine and cosmetics | GALDERMA RES & DEV | 2014-11-19 | — | — | CN | disclosed |
| EP-2183228-B1 | CYCLIC INHIBITORS OF 11ß -HYDROXYSTERIOD DEHYDROGENASE 1 | VITAE PHARMACEUTICALS INC (US) | 2014-08-20 | — | — | EP | disclosed |
| US-8575156-B2 | Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1 | VITAE PHARMACEUTICALS, INC. (US) | 2013-11-05 | — | — | US | disclosed |
| CN-102224139-A | Novel 4- (azacycloalkyl) benzene-1, 3-diol compounds as tyrosinase inhibitors, process for their preparation and their use in human medicine and cosmetics | GALDERMA RES & DEV | 2011-10-19 | — | — | CN | disclosed |
| US-20110015157-A1 | CYCLIC INHIBITORS OF 11BETA-HYDROXYSTEROID DEHYDROGENASE 1 | Vitae Pharmaceuticals ,Inc. | 2011-01-20 | — | — | US | disclosed |
| EP-2183228-A1 | CYCLIC INHIBITORS OF 11ß -HYDROXYSTERIOD DEHYDROGENASE 1 | Vitae Pharmaceuticals, Inc. (US) | 2010-05-12 | — | — | EP | disclosed |
| WO-2009017664-A1 | CYCLIC INHIBITORS OF 11β-HYDROXYSTERIOD DEHYDROGENASE 1 | VITAE PHARMACEUTICALS, INC. (US) | 2009-02-05 | — | — | WO | disclosed |
| EP-0436722-B1 | POLYSACCHARIDE DERIVATIVES AND SEPARATING AGENT | DAICEL CHEM (JP) | 1997-05-07 | — | — | EP | disclosed |
| US-5202433-A | For racemic mixtures | DAICEL CHEMICAL INDUSTRIES, LTD. (JP) | 1993-04-13 | — | — | US | disclosed |
| EP-0436722-A1 | POLYSACCHARIDE DERIVATIVES AND SEPARATING AGENT | DAICEL CHEMICAL INDUSTRIES, LTD. (JP) | 1991-07-17 | — | — | EP | disclosed |
| US-4242122-A | CARBAMOYL-OXY AND -THIO DERIVATIVES OF PHENYLUREA | MONSANTO COMPANY (US) | 1980-12-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110015157-A1 | CYCLIC INHIBITORS OF 11BETA-HYDROXYSTEROID DEHYDROGENASE 1 | HSD11B1, HSD11B2, HSD3B1 | CHRNA7 2594/4885MIF 148/4885ACHE 3450/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.