Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 4/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | SLC29A1 | Q99808 | 4/20 | 0.54 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.52 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.52 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.52 |
| ▸ | DRD2 | P14416 | 4/20 | 0.51 |
| ▸ | DRD4 | P21917 | 4/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | TSHR | P16473 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9559605 | 0.91 | TP53 (0.57) | TP53LMNAMAPTMAPK1SLC29A1 | |
| SCHEMBL9559731 | 0.90 | THRB (0.59) | TP53LMNAMAPTSLC29A1CACNA1G | |
| SCHEMBL9559610 | 0.90 | TP53 (0.56) | TP53LMNAMAPTMAPK1ALOX15 | |
| SCHEMBL9559661 | 0.89 | TP53 (0.51) | TP53LMNAMAPTMAPK1ALOX15 | |
| SCHEMBL9559709 | 0.85 | DRD2 (0.55) | TP53LMNAMAPK1SLC29A1CACNA1G | |
| SCHEMBL9559855 | 0.85 | TP53 (0.59) | TP53LMNASLC29A1HTR4ADORA2B | |
| SCHEMBL9559712 | 0.84 | CACNA1G (0.57) | TP53LMNAMAPTCACNA1GDRD2 | |
| SCHEMBL9132937 | 0.84 | SLC29A1 (0.70) | TP53LMNAMAPK1SLC29A1SMN1; SMN2 | |
| SCHEMBL9559698 | 0.83 | DRD2 (0.62) | TP53CACNA1GDRD2MEN1KMT2A | |
| SCHEMBL5655987 | 0.83 | NPSR1 (0.69) | LMNAMAPTCACNA1GHTR4DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0544765-A1 | PIPERAZINYL DERIVATIVES. | NOVO NORDISK AS (DK) | 1993-06-09 | — | — | EP | claimed |
| WO-1992003426-A1 | PIPERAZINYL DERIVATIVES | NOVO NORDISK A/S (DK) | 1992-03-05 | — | — | WO | claimed |
| US-5246935-A | Cardiovascular and gastrointestinal | NOVO NORDISK A/S (DK) | 1993-09-21 | — | — | US | disclosed |
| EP-0544765-A1 | PIPERAZINYL DERIVATIVES. | NOVO NORDISK AS (DK) | 1993-06-09 | — | — | EP | disclosed |
| WO-1992003426-A1 | PIPERAZINYL DERIVATIVES | NOVO NORDISK A/S (DK) | 1992-03-05 | — | — | WO | disclosed |