Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | USP2 | O75604 | 2/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | CACNA1G | O43497 | 3/20 | 0.53 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.53 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.53 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.52 |
| ▸ | DRD2 | P14416 | 2/20 | 0.51 |
| ▸ | DRD4 | P21917 | 1/20 | 0.51 |
| ▸ | DRD3 | P35462 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9559704 | 0.91 | THRB (0.57) | THRBLMNAUSP2L3MBTL1TP53 | |
| SCHEMBL9559630 | 0.90 | TP53 (0.56) | LMNAUSP2TP53KCNH2MAPT | |
| SCHEMBL9559576 | 0.87 | HTR2A (0.61) | LMNAUSP2TP53MAPTHTR4 | |
| SCHEMBL5654244 | 0.85 | L3MBTL1 (0.75) | THRBL3MBTL1KCNH2MAPTMEN1 | |
| SCHEMBL9559709 | 0.85 | DRD2 (0.55) | LMNATP53KCNH2MEN1KMT2A | |
| SCHEMBL9559605 | 0.85 | TP53 (0.57) | LMNATP53KCNH2MAPTMEN1 | |
| SCHEMBL11166971 | 0.84 | L3MBTL1 (0.54) | THRBLMNAUSP2L3MBTL1KCNH2 | |
| SCHEMBL9559610 | 0.84 | TP53 (0.56) | LMNAL3MBTL1TP53KCNH2MAPT | |
| SCHEMBL9559698 | 0.83 | DRD2 (0.62) | TP53MEN1KMT2ACACNA1GDRD2 | |
| SCHEMBL9132937 | 0.82 | SLC29A1 (0.70) | LMNATP53KCNH2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0544765-A1 | PIPERAZINYL DERIVATIVES. | NOVO NORDISK AS (DK) | 1993-06-09 | — | — | EP | claimed |
| WO-1992003426-A1 | PIPERAZINYL DERIVATIVES | NOVO NORDISK A/S (DK) | 1992-03-05 | — | — | WO | claimed |