Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.64 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.50 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.50 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.50 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.50 |
| ▸ | DRD2 | P14416 | 3/20 | 0.47 |
| ▸ | DRD4 | P21917 | 3/20 | 0.47 |
| ▸ | DRD3 | P35462 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5661129 | 0.96 | ALDH1A1 (0.58) | ALDH1A1MAPK1HDAC3HDAC4HDAC1 | |
| SCHEMBL5660852 | 0.96 | ALDH1A1 (0.58) | ALDH1A1MAPK1HDAC3HDAC4HDAC1 | |
| SCHEMBL3394436 | 0.93 | ALDH1A1 (0.61) | ALDH1A1MAPK1HDAC3HDAC4HDAC1 | |
| SCHEMBL5167895 | 0.87 | ALDH1A1 (0.74) | ALDH1A1MAPK1HDAC3HDAC4HDAC1 | |
| SCHEMBL5169003 | 0.87 | ALDH1A1 (0.74) | ALDH1A1MAPK1HDAC3HDAC4HDAC1 | |
| SCHEMBL123612 | 0.85 | ALDH1A1 (0.70) | ALDH1A1MAPK1HDAC3HDAC4HDAC1 | |
| SCHEMBL420011 | 0.85 | ALDH1A1 (0.78) | ALDH1A1MAPK1HDAC3HDAC4HDAC1 | |
| SCHEMBL1931125 | 0.85 | ALDH1A1 (0.78) | ALDH1A1MAPK1HDAC3HDAC4HDAC1 | |
| SCHEMBL9038943 | 0.80 | ALDH1A1 (0.50) | ALDH1A1MAPK1HDAC3HDAC4HDAC1 | |
| SCHEMBL7414719 | 0.79 | HDAC3 (0.54) | ALDH1A1MAPK1HDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 82 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110130482-A1 | Process for preparing armatic thiophenyl ketones | PRETOR ROGER | 2011-06-02 | — | — | US | claimed |
| EP-1799638-B1 | PROCESS FOR PREPARING AROMATIC THIOPHENYL KETONES | CIBA HOLDING INC (CH) | 2008-07-30 | — | — | EP | claimed |
| CN-101031543-A | Process for preparing aromatic thiophenyl ketones | CIBA SC HOLDING AG (CH) | 2007-09-05 | — | — | CN | claimed |
| EP-1799638-A1 | PROCESS FOR PREPARING AROMATIC THIOPHENYL KETONES | CIBA SPECIALTY CHEMICALS HOLDING INC. Patent Departement (CH) | 2007-06-27 | — | — | EP | claimed |
| WO-2006034966-A1 | PROCESS FOR PREPARING AROMATIC THIOPHENYL KETONES | CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) | 2006-04-06 | — | — | WO | claimed |
| US-11236061-B2 | Xanthene-based compound and photosensitive resin composition comprising same | LG CHEM, LTD. (KR) | 2022-02-01 | — | — | US | disclosed |
| US-20180250308-A1 | NR2B SELECTIVE NMDA-RECEPTOR ANTAGONISTS FOR TREATMENT OF IMMUNE-MEDIATED INFLAMMATORY DISEASES | WESTFALISCHE WILHELMS-UNIVERSITAT MUNSTER (DE) | 2018-09-06 | — | — | US | disclosed |
| EP-3344257-A1 | NR2B SELECTIVE NMDA-RECEPTOR ANTAGONISTS FOR TREATMENT OF IMMUNE-MEDIATED INFLAMMATORY DISEASES | Westfälische Wilhelms-Universität Münster (DE) | 2018-07-11 | — | — | EP | disclosed |
| WO-2017036880-A1 | NR2B SELECTIVE NMDA-RECEPTOR ANTAGONISTS FOR TREATMENT OF IMMUNE-MEDIATED INFLAMMATORY DISEASES | Westfälische Wilhelms-Universität Münster (DE) | 2017-03-09 | — | — | WO | disclosed |
| EP-2121594-B1 | QUATERNARY AMMONIUM DIPHENYLMETHYL COMPOUNDS USEFUL AS MUSCARINIC RECEPTOR ANTAGONISTS | THERAVANCE BIOPHARMA R & D IP LLC (US) | 2015-10-21 | — | — | EP | disclosed |
| US-8802856-B2 | Quaternary ammonium diphenylmethyl compounds useful as muscarinic receptor antagonists | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2014-08-12 | — | — | US | disclosed |
| US-20140051864-A1 | QUATERNARY AMMONIUM DIPHENYLMETHYL COMPOUNDS USEFUL AS MUSCARINIC RECEPTOR ANTAGONISTS | THERAVANCE, INC. (US) | 2014-02-20 | — | — | US | disclosed |
| EP-0072307-A1 | Piperazine derivatives of theophylline | LABORATOIRES SYNTEX (FR) | 1983-02-16 | — | — | EP | disclosed |
| EP-0071543-A1 | Piperazine derivatives of theobromine | LABORATOIRES SYNTEX (FR) | 1983-02-09 | — | — | EP | disclosed |
| EP-0066415-A2 | N-(arylthioalkyl)-N'-(aminoalkyl)ureas | A.H. ROBINS COMPANY, INCORPORATED (US) | 1982-12-08 | — | — | EP | disclosed |
| EP-0033674-A2 | Piperazine derivatives of theophylline | LAROCHE NAVARRON S.A. Société dite: (FR) | 1981-08-12 | — | — | EP | disclosed |
| US-4127661-A | VASODILATOR | SERDEX - SOCIETE D'ETUDES, DE RECHERCHES, DE DIFFUSION ET D'EXPLOITATION (FR) | 1978-11-28 | — | — | US | disclosed |
| US-4101670-A | THIOLCARBAMATES | KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) | 1978-07-18 | — | — | US | disclosed |
| US-4017631-A | MICROBIOCIDES | JANSSEN PHARMACEUTICA N.V. (BE) | 1977-04-12 | — | — | US | disclosed |
| US-3991202-A | ANTIMICROBIALS | JANSSEN PHARMACEUTICA N.V. (BE) | 1976-11-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110130482-A1 | Process for preparing armatic thiophenyl ketones | ACOT7, AGPAT2, COASY | ALDH1A1 1816/4885MAPK1 3795/4885HDAC3 2974/4885 |
| US-11236061-B2 | Xanthene-based compound and photosensitive resin composition comprising same | RER1, TAS1R1, SUN2 | ALDH1A1 1289/4885MAPK1 728/4885HDAC3 4635/4885 |
| US-20180250308-A1 | NR2B SELECTIVE NMDA-RECEPTOR ANTAGONISTS FOR TREATMENT OF IMMUNE-MEDIATED INFLAMMATORY DISEASES | GRIN1, GRIN2B, GRIN3B | ALDH1A1 2771/4885MAPK1 2708/4885HDAC3 696/4885 |
| US-20140051864-A1 | QUATERNARY AMMONIUM DIPHENYLMETHYL COMPOUNDS USEFUL AS MUSCARINIC RECEPTOR ANTAGONISTS | CHRM2, CHRM5, CHRM1 | ALDH1A1 1852/4885MAPK1 1708/4885HDAC3 1323/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.