SCHEMBL9560848

SCHEMBL9560848

CCOc1ccc(C(Cl)(COCc2cccc(Oc3ccc(Cl)cc3)c2)C(F)(F)F)cc1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.42
LTA4H P09960 2/20 0.38
CETP P11597 2/20 0.38
MAPK1 P28482 1/20 0.38
FFAR1 O14842 4/20 0.37
LMNA P02545 3/20 0.37
MAPT P10636 2/20 0.37
ATM Q13315 1/20 0.37
L3MBTL1 Q9Y468 1/20 0.37
PPARG P37231 1/20 0.36
PPARA Q07869 1/20 0.36
MRGPRX4 Q96LA9 2/20 0.35
SMN1; SMN2 Q16637 2/20 0.35
TP53 P04637 1/20 0.35
PKM P14618 1/20 0.35
NFKB1 P19838 1/20 0.35
NFKB2 Q00653 1/20 0.35
RELA Q04206 1/20 0.35
FFAR4 Q5NUL3 2/20 0.35
GAA P10253 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9560713 0.94 LTA4H (0.46) ALDH1A1LTA4HCETPMAPK1FFAR1
SCHEMBL9561663 0.90 ALDH1A1 (0.39) ALDH1A1CETPMAPK1FFAR1LMNA
SCHEMBL9561658 0.90 ALDH1A1 (0.39) ALDH1A1CETPMAPK1FFAR1LMNA
SCHEMBL9560806 0.88 ALDH1A1 (0.42) ALDH1A1LTA4HCETPMAPK1FFAR1
SCHEMBL9560874 0.88 ALDH1A1 (0.38) ALDH1A1CETPMAPK1FFAR1LMNA
SCHEMBL9560778 0.88 ALDH1A1 (0.39) ALDH1A1CETPFFAR1LMNAPPARG
SCHEMBL9560424 0.87 MAPK14 (0.40) ALDH1A1CETPLMNAPPARGPPARA
SCHEMBL9560497 0.87 ALDH1A1 (0.41) ALDH1A1LTA4HCETPMAPK1FFAR1
SCHEMBL10851891 0.86 ALDH1A1 (0.46) ALDH1A1LTA4HCETPMAPK1FFAR1
SCHEMBL9560836 0.84 MAPT (0.41) ALDH1A1LTA4HFFAR1LMNAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5225607-A Multistage etherification or dehydrohalogenation and reductive dechlorination IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1993-07-06 US disclosed
US-5196610-A INSECTICIDAL ETHERS IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1993-03-23 US disclosed
EP-0211561-B1 INSECTICIDAL ETHERS IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1992-03-11 EP disclosed
EP-0211561-A1 Insecticidal ethers IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1987-02-25 EP disclosed