Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 3/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | STAT3 | P40763 | 1/20 | 0.43 |
| ▸ | MMP13 | P45452 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5212608 | 0.84 | SMN1; SMN2 (0.64) | KDM1AHDAC1SMN1; SMN2POLBHTT | |
| SCHEMBL9561804 | 0.79 | NPC1 (0.53) | SMN1; SMN2KMT2AGAAROCK2MMP13 | |
| SCHEMBL5213342 | 0.74 | RAB9A (0.60) | SMN1; SMN2HTTLMNAKMT2AMAPT | |
| SCHEMBL1568232 | 0.72 | SMN1; SMN2 (0.74) | SMN1; SMN2POLBHTTLMNAL3MBTL1 | |
| SCHEMBL5215174 | 0.71 | EPHX2 (0.52) | KDM1AHDAC1SMN1; SMN2POLBHTT | |
| SCHEMBL14256291 | 0.71 | L3MBTL1 (0.67) | KDM1AHDAC1SMN1; SMN2POLBHTT | |
| SCHEMBL5213178 | 0.71 | CYP1A2 (0.64) | SMN1; SMN2POLBHTTLMNAKMT2A | |
| SCHEMBL5212711 | 0.71 | RAB9A (0.67) | KDM1AHDAC1SMN1; SMN2POLBL3MBTL1 | |
| SCHEMBL8358422 | 0.71 | MMP13 (0.68) | SMN1; SMN2HTTLMNAL3MBTL1ALDH1A1 | |
| SCHEMBL5209755 | 0.71 | SMN1; SMN2 (0.64) | SMN1; SMN2HTTLMNAL3MBTL1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5260323-A | 2,4- and 2,5-substituted pyridine-N-oxides, processes for their preparation and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-11-09 | — | — | US | disclosed |