Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 5/20 | 0.54 |
| ▸ | GABRA5 | P31644 | 5/20 | 0.54 |
| ▸ | GABRA2 | P47869 | 5/20 | 0.54 |
| ▸ | GABRB2 | P47870 | 5/20 | 0.54 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.54 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.54 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.54 |
| ▸ | CCKBR | P32239 | 1/20 | 0.54 |
| ▸ | BRD4 | O60885 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.44 |
| ▸ | BRD2 | P25440 | 1/20 | 0.43 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11508218 | 0.84 | OPRK1 (0.65) | GABRA1GABRA5GABRA2GABRB2GABRA3 | |
| SCHEMBL11508280 | 0.81 | CHRM1 (0.49) | GABRA1GABRA5GABRA2GABRB2GABRA3 | |
| SCHEMBL7311260 | 0.80 | OPRK1 (0.56) | GABRA1GABRA5GABRA2GABRB2GABRA3 | |
| SCHEMBL11509112 | 0.79 | LMNA (0.64) | GABRA1GABRA5GABRA2GABRB2GABRA3 | |
| SCHEMBL7324237 | 0.75 | BRD4 (0.81) | GABRA1GABRA5GABRA2GABRB2GABRA3 | |
| SCHEMBL9565451 | 0.73 | GABRA1 (0.52) | GABRA1GABRA5GABRA2GABRB2GABRA3 | |
| SCHEMBL1813858 | 0.72 | BRD4 (0.51) | GABRA1GABRA5GABRA2GABRB2GABRA3 | |
| SCHEMBL11508521 | 0.72 | GABRA1 (0.66) | GABRA1GABRA5GABRA2GABRB2GABRA3 | |
| SCHEMBL11800198 | 0.72 | OPRK1 (0.50) | GABRA1GABRA5GABRA2GABRB2GABRA3 | |
| SCHEMBL24156374 | 0.71 | OPRK1 (0.54) | GABRA1GABRA5GABRA2GABRB2GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0523846-A2 | 1,4-Benzodiazepines with 5-membered heterocyclic rings | MERCK & CO. INC. (US) | 1993-01-20 | — | — | EP | disclosed |
| EP-0272866-A1 | 1,4-Benzodiazepines with 5-membered heterocyclic rings | MERCK & CO. INC. (US) | 1988-06-29 | — | — | EP | disclosed |
| US-4169150-A | MUSCLE RELAXANTS, HYPNOSIS, ANTICONVULSANTS, SEDATIVES | TEIJIN LIMITED (JP) | 1979-09-25 | — | — | US | disclosed |