Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 3/20 | 0.51 |
| ▸ | GABRA1 | P14867 | 4/20 | 0.49 |
| ▸ | GABRA5 | P31644 | 4/20 | 0.49 |
| ▸ | GABRA2 | P47869 | 4/20 | 0.49 |
| ▸ | GABRB2 | P47870 | 4/20 | 0.49 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.49 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.49 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.49 |
| ▸ | CCKBR | P32239 | 1/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | CNR1 | P21554 | 1/20 | 0.46 |
| ▸ | BRD2 | P25440 | 1/20 | 0.42 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7324237 | 0.77 | BRD4 (0.81) | BRD4GABRA1GABRA5GABRA2GABRB2 | |
| SCHEMBL1810705 | 0.76 | GABRA1 (0.48) | BRD4GABRA1GABRA5GABRA2GABRB2 | |
| SCHEMBL7311260 | 0.73 | OPRK1 (0.56) | BRD4GABRA1GABRA5GABRA2GABRB2 | |
| SCHEMBL11826742 | 0.73 | GABRA5 (0.51) | BRD4GABRA1GABRA5GABRA2GABRB2 | |
| SCHEMBL11822943 | 0.73 | GABRA1 (0.69) | BRD4GABRA1GABRA5GABRA2GABRB2 | |
| SCHEMBL9565437 | 0.72 | GABRA1 (0.54) | BRD4GABRA1GABRA5GABRA2GABRB2 | |
| SCHEMBL11830576 | 0.71 | TDP1 (0.59) | BRD4GABRA1GABRA5GABRA2GABRB2 | |
| SCHEMBL11037044 | 0.71 | OPRK1 (0.56) | BRD4GABRA1GABRA5GABRA2GABRB2 | |
| SCHEMBL11836500 | 0.71 | GABRA1 (0.49) | BRD4GABRA1GABRA5GABRA2GABRB2 | |
| SCHEMBL11867115 | 0.70 | GABRA1 (0.45) | BRD4GABRA1GABRA5GABRA2GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1912653-B1 | HETEROCYCLIC BENZODIAZEPINE CGRP RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME (US) | 2014-01-01 | — | — | EP | disclosed |
| US-7947678-B2 | Heterocyclic benzodiazepine CGRP receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2011-05-24 | — | — | US | disclosed |
| US-20090105228-A1 | Heterocyclic benzodiazepine cgrp receptor antagonists | MERCK SHARP & DOHME LLC | 2009-04-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090105228-A1 | Heterocyclic benzodiazepine cgrp receptor antagonists | BDKRB2, BDKRB1, CCKBR | BRD4 751/4885GABRA1 32/4885GABRA5 48/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.