Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC1A3 | P43003 | 1/20 | 0.42 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.42 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.42 |
| ▸ | CASR | P41180 | 1/20 | 0.40 |
| ▸ | ITGAV | P06756 | 1/20 | 0.38 |
| ▸ | KYNU | Q16719 | 2/20 | 0.37 |
| ▸ | OTC | P00480 | 1/20 | 0.37 |
| ▸ | NOS3 | P29474 | 1/20 | 0.36 |
| ▸ | NOS1 | P29475 | 1/20 | 0.36 |
| ▸ | NOS2 | P35228 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | NPY4R | P50391 | 3/20 | 0.36 |
| ▸ | NPY1R | P25929 | 2/20 | 0.36 |
| ▸ | NPY2R | P49146 | 2/20 | 0.36 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.36 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL16553180 | 0.85 | SLC1A3 (0.45) | SLC1A3SLC1A2SLC1A1CASRNPY5R | |
| Arginine SCHEMBL16553181 | 0.85 | SLC1A3 (0.45) | SLC1A3SLC1A2SLC1A1CASRNPY5R | |
| Arginine SCHEMBL16552839 | 0.84 | CASR (0.44) | CASROTCPOLBKMT2ATDP1 | |
| Arginine SCHEMBL16553173 | 0.84 | CASR (0.44) | CASROTCPOLBKMT2ATDP1 | |
| Arginine SCHEMBL16879777 | 0.83 | KIF11 (0.47) | OTCNOS3NOS1NOS2POLB | |
| Arginine SCHEMBL956656 | 0.81 | ITGB3 (0.47) | SLC1A3SLC1A2SLC1A1CASROTC | |
| Arginine SCHEMBL16553031 | 0.81 | ITGB3 (0.47) | SLC1A3SLC1A2SLC1A1CASROTC | |
| Arginine SCHEMBL6468370 | 0.81 | PMP22 (0.50) | OTCNOS3NOS1NOS2KMT2A | |
| Arginine SCHEMBL17874428 | 0.81 | PMP22 (0.50) | OTCNOS3NOS1NOS2KMT2A | |
| Arginine SCHEMBL6468371 | 0.81 | PMP22 (0.50) | OTCNOS3NOS1NOS2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101952348-B | Temperature-sensitive arginine-based hydrogel as biological carrier | UNIV CORNELL | 2013-08-07 | — | — | CN | claimed |
| CN-101952348-A | Temperature-sensitive arginine-based hydrogel as biological carrier | UNIV CORNELL | 2011-01-19 | — | — | CN | claimed |
| US-20110008441-A1 | THERMORESPONSIVE ARGININE-BASED HYDROGELS AS BIOLOGIC CARRIERS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2011-01-13 | — | — | US | claimed |
| EP-2222754-A2 | THERMORESPONSIVE ARGININE-BASED HYDROGELS AS BIOLOGIC CARRIERS | Cornell University (US) | 2010-09-01 | — | — | EP | claimed |
| WO-2009073541-A2 | THERMORESPONSIVE ARGININE-BASED HYDROGELS AS BIOLOGIC CARRIERS | CORNELL UNIVERSITY (US) | 2009-06-11 | — | — | WO | claimed |
| EP-2222754-B1 | THERMORESPONSIVE ARGININE-BASED HYDROGELS AS BIOLOGIC CARRIERS | UNIV CORNELL (US) | 2018-01-10 | — | — | EP | disclosed |
| US-8858998-B2 | Thermoresponsive arginine-based hydrogels as biologic carriers | CORNELL UNIVERSITY (US) | 2014-10-14 | — | — | US | disclosed |
| CN-101952348-B | Temperature-sensitive arginine-based hydrogel as biological carrier | UNIV CORNELL | 2013-08-07 | — | — | CN | disclosed |
| CN-101952348-A | Temperature-sensitive arginine-based hydrogel as biological carrier | UNIV CORNELL | 2011-01-19 | — | — | CN | disclosed |
| US-20110008441-A1 | THERMORESPONSIVE ARGININE-BASED HYDROGELS AS BIOLOGIC CARRIERS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2011-01-13 | — | — | US | disclosed |
| EP-2222754-A2 | THERMORESPONSIVE ARGININE-BASED HYDROGELS AS BIOLOGIC CARRIERS | Cornell University (US) | 2010-09-01 | — | — | EP | disclosed |
| WO-2009073541-A2 | THERMORESPONSIVE ARGININE-BASED HYDROGELS AS BIOLOGIC CARRIERS | CORNELL UNIVERSITY (US) | 2009-06-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110008441-A1 | THERMORESPONSIVE ARGININE-BASED HYDROGELS AS BIOLOGIC CARRIERS | PARG, PNISR, PUF60 | SLC1A3 1790/4885SLC1A2 2172/4885SLC1A1 2002/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.