Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.55 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | FADS1 | O60427 | 1/20 | 0.46 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9566795 | 0.89 | P4HTM (0.59) | TP53MAPTP4HTMALDH1A1SMN1; SMN2 | |
| SCHEMBL9566866 | 0.87 | KDM4E (0.56) | MAPTP4HTMALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL9566751 | 0.87 | NPC1 (0.52) | P4HTMNR1H4THRBALDH1A1SMN1; SMN2 | |
| SCHEMBL9566778 | 0.85 | P4HTM (0.61) | TP53MAPTP4HTMALDH1A1SMN1; SMN2 | |
| SCHEMBL9566789 | 0.83 | P4HTM (0.60) | TP53MAPTP4HTMNR1H4ALDH1A1 | |
| SCHEMBL9566807 | 0.83 | P4HTM (0.59) | TP53MAPTP4HTMALDH1A1SMN1; SMN2 | |
| SCHEMBL9566888 | 0.81 | P4HTM (0.57) | TP53MAPTP4HTMALDH1A1SMN1; SMN2 | |
| SCHEMBL9566740 | 0.81 | CXCR2 (0.54) | P4HTMALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL12020444 | 0.81 | P4HTM (0.62) | TP53MAPTP4HTMNR1H4ALDH1A1 | |
| SCHEMBL9566797 | 0.80 | P4HTM (0.67) | MAPTP4HTMALDH1A1SMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0533130-A1 | 2-Hydroxymethylpyridines, the corresponding pyridine-N-oxides and derivatives thereof, process for their preparation and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-03-24 | — | — | EP | disclosed |