Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.52 |
| ▸ | RAB9A | P51151 | 4/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | STAT3 | P40763 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.50 |
| ▸ | P4HTM | Q9NXG6 | 3/20 | 0.50 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.47 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.47 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.47 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.47 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.47 |
| ▸ | CHRNA10 | Q9GZZ6 | 1/20 | 0.47 |
| ▸ | CHRNA9 | Q9UGM1 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.47 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9566740 | 0.88 | CXCR2 (0.54) | ALDH1A1LMNASTAT3SMN1; SMN2P4HTM | |
| SCHEMBL9566866 | 0.88 | KDM4E (0.56) | NPC1RAB9AKDM4EALDH1A1LMNA | |
| SCHEMBL9566737 | 0.88 | NPC1 (0.57) | NPC1RAB9AKDM4EALDH1A1TRPV1 | |
| SCHEMBL9566779 | 0.87 | TP53 (0.55) | NPC1RAB9AALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL9566798 | 0.86 | MAPT (0.60) | NPC1RAB9AKDM4EALDH1A1LMNA | |
| SCHEMBL9566892 | 0.84 | PLK1 (0.53) | NPC1RAB9ALMNASTAT3SMN1; SMN2 | |
| SCHEMBL9566842 | 0.84 | SENP7 (0.53) | NPC1RAB9AKDM4EALDH1A1LMNA | |
| SCHEMBL6931023 | 0.83 | CXCR1 (0.60) | NPC1RAB9AKDM4EALDH1A1TRPV1 | |
| SCHEMBL9566756 | 0.83 | RAB9A (0.57) | NPC1RAB9AKDM4EALDH1A1LMNA | |
| SCHEMBL9566764 | 0.82 | TRPV1 (0.60) | NPC1RAB9AKDM4EALDH1A1TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0533130-A1 | 2-Hydroxymethylpyridines, the corresponding pyridine-N-oxides and derivatives thereof, process for their preparation and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-03-24 | — | — | EP | disclosed |