SCHEMBL9567016

SCHEMBL9567016

Cn1c(C(F)(F)F)cc(=O)n(-c2ccc(Cl)c(C(=O)C3CC3)c2)c1=O

nearest known ligand 0.36

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
CTSB P07858 1/20 0.36
TDP1 Q9NUW8 1/20 0.36
NOTUM Q6P988 12/20 0.35
CRHR1 P34998 1/20 0.34
NPC1 O15118 1/20 0.34
RAB9A P51151 1/20 0.34
MEN1 O00255 1/20 0.34
KMT2A Q03164 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
CHRNA7 P36544 1/20 0.33
HSD11B1 P28845 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9567015 0.96 CTSB (0.35) CTSBTDP1NOTUMCRHR1MEN1
SCHEMBL9567019 0.95 CFTR (0.35) CTSBTDP1NOTUMCRHR1MEN1
SCHEMBL1807362 0.85 TDP1 (0.52) CTSBTDP1NOTUMMEN1KMT2A
SCHEMBL9423041 0.85 TDP1 (0.40) CTSBTDP1NOTUMMEN1KMT2A
SCHEMBL29576263 0.85 TDP1 (0.40) CTSBTDP1NOTUMCRHR1MEN1
SCHEMBL9168174 0.85 TDP1 (0.40) CTSBTDP1NOTUMCRHR1MEN1
SCHEMBL9423187 0.84 TDP1 (0.38) CTSBTDP1NOTUMCRHR1CHRNA7
SCHEMBL6465173 0.84 LMNA (0.47) CTSBTDP1NOTUMMEN1KMT2A
Ethylene SCHEMBL9423310 0.83 TDP1 (0.39) CTSBTDP1NOTUMMEN1KMT2A
SCHEMBL8993584 0.83 MEN1 (0.37) CRHR1MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0542685-A1 3-Aryluracile derivatives and their use against weeds CIBA-GEIGY AG (CH) 1993-05-19 EP claimed
EP-0542685-A1 3-Aryluracile derivatives and their use against weeds CIBA-GEIGY AG (CH) 1993-05-19 EP disclosed