Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | ENPP2 | Q13822 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
| ▸ | PLG | P00747 | 1/20 | 0.40 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.40 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.40 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.40 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.40 |
| ▸ | TPSD1 | Q9BZJ3 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9568212 | 1.00 | SMN1; SMN2 (0.45) | SMN1; SMN2NPC1RAB9AHTTCYP2C19 | |
| SCHEMBL9568143 | 0.89 | PRSS1 (0.53) | SMN1; SMN2NPC1RAB9ACYP2C19ENPP2 | |
| SCHEMBL9568138 | 0.89 | PRSS1 (0.53) | SMN1; SMN2NPC1RAB9ACYP2C19ENPP2 | |
| SCHEMBL9568210 | 0.83 | SCN1A (0.44) | SMN1; SMN2NPC1RAB9AMEN1KMT2A | |
| SCHEMBL9568208 | 0.83 | SCN1A (0.44) | SMN1; SMN2NPC1RAB9AMEN1KMT2A | |
| SCHEMBL9568179 | 0.79 | YAP1 (0.44) | SMN1; SMN2NPC1RAB9AHTTCYP2C19 | |
| SCHEMBL8407972 | 0.77 | SMN1; SMN2 (0.51) | SMN1; SMN2NPC1RAB9ACYP2C19MAPT | |
| SCHEMBL9568114 | 0.75 | F2 (0.44) | SMN1; SMN2NPC1RAB9AHTTENPP2 | |
| SCHEMBL9568104 | 0.74 | SMN1; SMN2 (0.48) | SMN1; SMN2NPC1RAB9AHTTCYP2C19 | |
| SCHEMBL9169401 | 0.74 | CCR1 (0.47) | SMN1; SMN2NPC1RAB9AALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0574808-A1 | Amidine-biphenyl derivatives, process for their production & medical preparation containing them | Dr. Karl Thomae GmbH (DE) | 1993-12-22 | — | — | EP | disclosed |