Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 3/20 | 0.36 |
| ▸ | TOP2A | P11388 | 5/20 | 0.35 |
| ▸ | TOP2B | Q02880 | 5/20 | 0.35 |
| ▸ | TOP1 | P11387 | 4/20 | 0.35 |
| ▸ | DHODH | Q02127 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | GSK3A | P49840 | 1/20 | 0.34 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.34 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9568342 | 0.94 | TOP1 (0.34) | GSK3BTOP2ATOP2BTOP1DHODH | |
| SCHEMBL9568346 | 0.91 | TOP1 (0.40) | GSK3BTOP1PIM1GSK3APIM3 | |
| SCHEMBL9568309 | 0.89 | ALDH1A1 (0.39) | KDM4EHPGDPOLB | |
| SCHEMBL9568348 | 0.88 | LMNA (0.39) | GSK3BTOP2ATOP2BTOP1DHODH | |
| SCHEMBL9568343 | 0.87 | TOP2A (0.42) | GSK3BTOP2ATOP2BPIM1GSK3A | |
| SCHEMBL9231972 | 0.86 | GSK3B (0.37) | GSK3BTOP2ATOP2BTOP1DHODH | |
| SCHEMBL9568311 | 0.85 | TOP1 (0.41) | GSK3BTOP1PIM1GSK3APIM3 | |
| SCHEMBL9568349 | 0.84 | MAPT (0.38) | KDM4EHPGDPOLB | |
| SCHEMBL9523210 | 0.82 | KDM4E (0.43) | GSK3BTOP1PIM1GSK3APIM3 | |
| SCHEMBL9568312 | 0.81 | TOP2A (0.41) | GSK3BTOP2ATOP2BTOP1PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0551518-A1 | QUINOLINECARBOXYLIC ACID DERIVATIVE | NIPPON SHINYAKU COMPANY, LIMITED (JP) | 1993-07-21 | — | — | EP | disclosed |