Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 4/20 | 0.57 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | XPO1 | O14980 | 1/20 | 0.45 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8947234 | 0.85 | POLB (0.60) | POLBHTTL3MBTL1XPO1GRIN1 | |
| SCHEMBL8947354 | 0.83 | POLB (0.65) | POLBHTTL3MBTL1XPO1GRIN1 | |
| SCHEMBL9568925 | 0.82 | ALDH1A1 (0.54) | POLBHTTALDH1A1HPGDMEN1 | |
| SCHEMBL9568758 | 0.79 | ALDH1A1 (0.41) | POLBHTTL3MBTL1ALDH1A1HPGD | |
| SCHEMBL9568853 | 0.78 | ALDH1A1 (0.65) | POLBHTTL3MBTL1SLC6A2SLC6A4 | |
| SCHEMBL8947128 | 0.76 | MAPK1 (0.53) | POLBHTTL3MBTL1ALDH1A1HPGD | |
| SCHEMBL9557277 | 0.74 | MAPK1 (0.41) | POLBHTTL3MBTL1ALDH1A1HPGD | |
| SCHEMBL9568731 | 0.74 | MAPK1 (0.41) | POLBHTTL3MBTL1ALDH1A1HPGD | |
| SCHEMBL9568841 | 0.74 | KMT2A (0.51) | POLBL3MBTL1ALDH1A1HPGDNPSR1 | |
| SCHEMBL9568919 | 0.73 | ALDH1A1 (0.39) | POLBHTTL3MBTL1ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5262433-A | Antidiabetic agents | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1993-11-16 | — | — | US | disclosed |
| EP-0528277-A1 | Tetrazoleacetic acid derivatives aldose reductase inhibitors | Wakamoto Pharmaceutical Co., Ltd. (JP) | 1993-02-24 | — | — | EP | disclosed |