SCHEMBL9568919

SCHEMBL9568919

O=C(Cn1nnnc1-c1ccc2ccsc2c1)OCCO

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.39
HPGD P15428 3/20 0.39
MAPK1 P28482 1/20 0.36
SIGMAR1 Q99720 1/20 0.35
TSHR P16473 3/20 0.33
HSD17B10 Q99714 2/20 0.33
MAPT P10636 2/20 0.32
POLB P06746 2/20 0.32
NPSR1 Q6W5P4 4/20 0.31
KDM4E B2RXH2 1/20 0.31
L3MBTL1 Q9Y468 1/20 0.31
HSD11B1 P28845 4/20 0.31
HTT P42858 2/20 0.31
TP53 P04637 1/20 0.31
HDAC3 O15379 1/20 0.31
HDAC4 P56524 1/20 0.31
HDAC1 Q13547 1/20 0.31
HDAC7 Q8WUI4 1/20 0.31
HDAC2 Q92769 1/20 0.31
HDAC10 Q969S8 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9568773 0.83 ALDH1A1 (0.56) ALDH1A1HPGDSIGMAR1POLBHSD11B1
SCHEMBL9568758 0.82 ALDH1A1 (0.41) ALDH1A1HPGDMAPK1TSHRMAPT
SCHEMBL9557277 0.78 MAPK1 (0.41) ALDH1A1HPGDMAPK1HSD17B10MAPT
SCHEMBL9568853 0.77 ALDH1A1 (0.65) ALDH1A1HPGDMAPK1HSD17B10MAPT
SCHEMBL9568925 0.77 ALDH1A1 (0.54) ALDH1A1HPGDMAPK1TSHRMAPT
SCHEMBL9568841 0.75 KMT2A (0.51) ALDH1A1HPGDMAPK1TSHRHSD17B10
SCHEMBL9568775 0.73 NPSR1 (0.50) ALDH1A1HPGDMAPK1TSHRMAPT
SCHEMBL9568735 0.73 MAPK1 (0.40) ALDH1A1HPGDMAPK1TSHRHSD17B10
SCHEMBL9568731 0.73 MAPK1 (0.41) ALDH1A1HPGDMAPK1TSHRHSD17B10
SCHEMBL9568720 0.72 MAPK1 (0.43) ALDH1A1HPGDMAPK1HSD11B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5262433-A Antidiabetic agents WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) 1993-11-16 US disclosed
EP-0528277-A1 Tetrazoleacetic acid derivatives aldose reductase inhibitors Wakamoto Pharmaceutical Co., Ltd. (JP) 1993-02-24 EP disclosed