SCHEMBL9568808

SCHEMBL9568808

FC(F)(F)c1cccc(-c2n[c]cs2)c1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.45
SMN1; SMN2 Q16637 1/20 0.44
NOTUM Q6P988 2/20 0.42
IDO1 P14902 1/20 0.42
MEN1 O00255 2/20 0.41
KMT2A Q03164 2/20 0.41
KDM4E B2RXH2 1/20 0.41
ALPL P05186 1/20 0.41
ALPI P09923 1/20 0.41
SCN2A Q99250 2/20 0.41
TLR7 Q9NYK1 1/20 0.41
CTSS P25774 1/20 0.40
MAPT P10636 1/20 0.39
GAA P10253 1/20 0.39
MAPK1 P28482 1/20 0.39
RAB9A P51151 1/20 0.39
DYRK1A Q13627 1/20 0.39
DYRK2 Q92630 1/20 0.39
PIM1 P11309 1/20 0.39
AR P10275 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2753490 0.83 IKBKB (0.36) MAPTIKBKB
SCHEMBL2092788 0.80 KIF11 (0.44) ALDH1A1MEN1KMT2AKDM4ETLR7
SCHEMBL694798 0.78 KDM4E (0.47) ALDH1A1SMN1; SMN2NOTUMIDO1MEN1
SCHEMBL9568881 0.77 DYRK1A (0.43) CTSSDYRK1APIM1
SCHEMBL2752090 0.75 NOTUM (0.41) NOTUM
SCHEMBL7510817 0.75 RAB9A (0.44) ALDH1A1SMN1; SMN2IDO1MEN1KMT2A
SCHEMBL7507911 0.75 CYP19A1 (0.42) ALDH1A1SMN1; SMN2NOTUMIDO1MEN1
SCHEMBL17028963 0.74 ALDH1A1 (0.44) ALDH1A1SMN1; SMN2NOTUMIDO1MEN1
SCHEMBL2749974 0.73 CES2 (0.37) KDM4E
SCHEMBL2750143 0.73 CES2 (0.37) GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0556123-A1 Pyrethrinoid esters of thiazolylalcohols, process for their preparation and their use as pesticides ROUSSEL UCLAF (FR) 1993-08-18 EP disclosed