Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 2/20 | 0.41 |
| ▸ | TOP2A | P11388 | 8/20 | 0.37 |
| ▸ | TOP2B | Q02880 | 8/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | PPARA | Q07869 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9569190 | 0.90 | TOP1 (0.33) | TOP1TOP2ATOP2BPPARA | |
| SCHEMBL9569145 | 0.86 | TOP1 (0.31) | TOP1PPARAKDM4ELMNA | |
| SCHEMBL9569183 | 0.83 | KDM4E (0.51) | TOP1TOP2ATOP2BHPGDKDM4E | |
| SCHEMBL9560362 | 0.81 | TOP1 (0.49) | TOP1TOP2ATOP2BHPGDKDM4E | |
| SCHEMBL9569179 | 0.78 | TOP2A (0.47) | TOP1TOP2ATOP2BKDM4EALDH1A1 | |
| SCHEMBL9569186 | 0.75 | KDM4E (0.43) | TOP1TOP2ATOP2BHPGDKDM4E | |
| SCHEMBL9509558 | 0.75 | TOP1 (0.52) | TOP1TOP2ATOP2BKDM4EPOLB | |
| SCHEMBL9509708 | 0.73 | TOP1 (0.52) | TOP1TOP2ATOP2BHPGDKDM4E | |
| SCHEMBL9560538 | 0.71 | TOP1 (0.45) | TOP1TOP2ATOP2BGSK3BKDM4E | |
| SCHEMBL9560364 | 0.70 | TOP1 (0.38) | TOP1TOP2ATOP2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0563734-A1 | 9-fluoro-7-oxo-7H-pyrido(1,2,3-de)(1,4)benzoxazine carboxylic acids and esters and their use as antiviral agents | BAYER AG (DE) | 1993-10-06 | — | — | EP | disclosed |