Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APEX1 | P27695 | 1/20 | 0.45 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | MMP13 | P45452 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.42 |
| ▸ | TPSAB1 | Q15661 | 3/20 | 0.41 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | F10 | P00742 | 1/20 | 0.41 |
| ▸ | PLG | P00747 | 1/20 | 0.41 |
| ▸ | PLAU | P00749 | 1/20 | 0.41 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.41 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.41 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.40 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9598107 | 0.88 | APEX1 (0.45) | APEX1MMP2MMP13CHRM1KDM4E | |
| SCHEMBL9028459 | 0.86 | F10 (0.55) | MMP2MMP13CHEK2TPSAB1PRSS1 | |
| SCHEMBL22533832 | 0.84 | MMP2 (0.50) | MMP2MMP13CHEK2TPSAB1PRSS1 | |
| SCHEMBL7050481 | 0.83 | HDAC6 (0.59) | CHRM1KDM4ECHEK2MAPTALDH1A1 | |
| SCHEMBL6374805 | 0.80 | HDAC6 (0.51) | MAPTALDH1A1 | |
| SCHEMBL7406681 | 0.80 | F10 (0.68) | TPSAB1PRSS1F2F10PLG | |
| SCHEMBL6368287 | 0.79 | PKM (0.44) | APEX1KDM4ECHEK2MAPT | |
| SCHEMBL9570064 | 0.78 | MAPT (0.55) | CHRM1KDM4EMAPTALDH1A1 | |
| SCHEMBL11887806 | 0.78 | APEX1 (0.64) | APEX1CHRM1KDM4ENPSR1PRKAG1 | |
| SCHEMBL548419 | 0.77 | F10 (0.63) | TPSAB1PRSS1F2F10PLG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5270322-A | Imidazo[1,2-a]pyridines, pharmaceutical compositions containing these compounds and processes for preparing them | DR. KARL THOMAE GMBH (DE) | 1993-12-14 | — | — | US | disclosed |
| EP-0555825-A1 | Imidazo(1,2-a)pyridines as angiotensin-II-antagonists | Dr. Karl Thomae GmbH (DE) | 1993-08-18 | — | — | EP | disclosed |