Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
| ▸ | DRD4 | P21917 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | HTR1A | P08908 | 2/20 | 0.46 |
| ▸ | HTR7 | P34969 | 1/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 4/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.46 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9017194 | 0.83 | RECQL (0.69) | RECQLDRD2DRD4LMNAMAPT | |
| SCHEMBL9017189 | 0.80 | RECQL (0.53) | RECQLDRD2DRD4LMNAMAPT | |
| SCHEMBL9017199 | 0.79 | HTR3E (0.53) | RECQLDRD2DRD4LMNAMAPT | |
| SCHEMBL9195086 | 0.73 | ADRA1D (0.63) | RECQLDRD2LMNAHTR1AADRA1D | |
| SCHEMBL9017186 | 0.71 | ADRA1D (0.73) | RECQLDRD2LMNAHTR1AADRA1D | |
| Hydrochloric Acid SCHEMBL9586428 | 0.70 | ADRA1D (0.72) | RECQLDRD2LMNAHTR1AHTR7 | |
| SCHEMBL8828619 | 0.70 | HTR3E (0.57) | DRD2DRD4LMNAMAPTALDH1A1 | |
| SCHEMBL9570977 | 0.70 | HTR3E (0.53) | DRD2DRD4LMNAMAPTALDH1A1 | |
| SCHEMBL15961234 | 0.69 | ADRA1D (0.63) | DRD2DRD4ADRA1DADRA1AADRA1B | |
| SCHEMBL7291084 | 0.69 | RECQL (0.71) | RECQLDRD2LMNAMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5244901-A | Multistage preparation by starting with a phenylpiperazine and an epoxide or chloro alcohol containing a phthalimido group; use to treat disorders involving hyperactivity of the alpha 1-adrenergic system | SYNTHELABO (FR) | 1993-09-14 | — | — | US | disclosed |
| EP-0522915-A1 | Pyrimidine-4-carboxamide derivatives, their preparation and their use in therapeutics | SYNTHELABO (FR) | 1993-01-13 | — | — | EP | disclosed |