Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.53 |
| ▸ | HTR3B | O95264 | 1/20 | 0.53 |
| ▸ | HTR3A | P46098 | 1/20 | 0.53 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.53 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.53 |
| ▸ | DRD2 | P14416 | 1/20 | 0.50 |
| ▸ | DRD4 | P21917 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | ADRA1D | P25100 | 7/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 7/20 | 0.46 |
| ▸ | ADRA1B | P35368 | 7/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TACR3 | P29371 | 1/20 | 0.43 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9017199 | 0.85 | HTR3E (0.53) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL7410473 | 0.81 | ALDH1A1 (0.68) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL8290816 | 0.79 | ADRA1D (0.59) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| Hydrochloric Acid SCHEMBL6935545 | 0.78 | ADRA1D (0.58) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL7549051 | 0.77 | DRD2 (0.65) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL9017194 | 0.76 | RECQL (0.69) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL27405596 | 0.76 | HTR3E (0.59) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL5650916 | 0.76 | HTR3E (0.59) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL9570990 | 0.75 | ADRA1D (0.72) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL4336114 | 0.74 | HTR3E (0.69) | HTR3EHTR3BHTR3AHTR3DHTR3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5244901-A | Multistage preparation by starting with a phenylpiperazine and an epoxide or chloro alcohol containing a phthalimido group; use to treat disorders involving hyperactivity of the alpha 1-adrenergic system | SYNTHELABO (FR) | 1993-09-14 | — | — | US | disclosed |
| EP-0522915-A1 | Pyrimidine-4-carboxamide derivatives, their preparation and their use in therapeutics | SYNTHELABO (FR) | 1993-01-13 | — | — | EP | disclosed |