Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | PKLR | P30613 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.41 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9574712 | 0.87 | P4HTM (0.57) | POLBALDH1A1P4HTMKDM4ETSHR | |
| SCHEMBL8869007 | 0.86 | POLB (0.59) | POLBALDH1A1PKLRMEN1KMT2A | |
| SCHEMBL9018005 | 0.86 | ALDH1A1 (0.53) | POLBALDH1A1PKLRMEN1KMT2A | |
| SCHEMBL7871609 | 0.81 | P4HTM (0.55) | P4HTMMAPK1 | |
| SCHEMBL7867912 | 0.79 | EGFR (0.47) | ALDH1A1MEN1KMT2ASMN1; SMN2P4HTM | |
| SCHEMBL7869173 | 0.79 | RAB9A (0.44) | ALDH1A1MEN1KMT2ASMN1; SMN2P4HTM | |
| SCHEMBL9018396 | 0.78 | ALDH1A1 (0.61) | POLBALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL9574775 | 0.77 | P4HTM (0.59) | ALDH1A1P4HTMKDM4ETSHRCYP1A2 | |
| SCHEMBL7871660 | 0.76 | SMN1; SMN2 (0.42) | POLBMEN1KMT2ASMN1; SMN2P4HTM | |
| SCHEMBL7871570 | 0.76 | EGFR (0.45) | KMT2AP4HTMGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0562512-A1 | Sulfonamido- and sulfonamidocarbonyl-pyridine-2-carboxamides and their pyridine-N-oxides, process for their preparation and their use as medicines | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-09-29 | — | — | EP | disclosed |