Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 1/20 | 0.48 |
| ▸ | PGR | P06401 | 1/20 | 0.48 |
| ▸ | AR | P10275 | 1/20 | 0.48 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 6/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | IDH2 | P48735 | 1/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | CDK7 | P50613 | 1/20 | 0.41 |
| ▸ | CCNH | P51946 | 1/20 | 0.41 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.41 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9574758 | 0.89 | NR3C1 (0.49) | NR3C1PGRARESR2KMT2A | |
| SCHEMBL8868444 | 0.88 | KDR (0.49) | NR3C1PGRARESR2KMT2A | |
| SCHEMBL8869093 | 0.81 | NR3C1 (0.52) | NR3C1PGRARESR2KMT2A | |
| SCHEMBL7870464 | 0.81 | BCL2L1 (0.45) | MAPTGAANPSR1L3MBTL1MAPK14 | |
| SCHEMBL9574871 | 0.79 | CACNA1B (0.48) | PGRGPR119FFAR1LMNAHTT | |
| SCHEMBL8869314 | 0.75 | POLB (0.55) | PGRFFAR1FFAR4LMNAHTT | |
| SCHEMBL8868123 | 0.73 | BCL2L1 (0.49) | MAPTKDRMAPK14MMP2MMP3 | |
| SCHEMBL8869647 | 0.72 | PGR (0.50) | NR3C1PGRARESR2KMT2A | |
| SCHEMBL7867676 | 0.71 | EPHX2 (0.42) | KMT2AMEN1SMN1; SMN2MMP13ALDH1A1 | |
| SCHEMBL9574709 | 0.71 | FEN1 (0.40) | NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0562512-A1 | Sulfonamido- and sulfonamidocarbonyl-pyridine-2-carboxamides and their pyridine-N-oxides, process for their preparation and their use as medicines | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-09-29 | — | — | EP | disclosed |