Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 1/20 | 0.49 |
| ▸ | PGR | P06401 | 1/20 | 0.49 |
| ▸ | AR | P10275 | 1/20 | 0.49 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | CDK8 | P49336 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | XBP1 | P17861 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9574828 | 0.89 | NR3C1 (0.48) | NR3C1PGRARESR2GAA | |
| SCHEMBL8869093 | 0.87 | NR3C1 (0.52) | NR3C1PGRARESR2GAA | |
| SCHEMBL7870464 | 0.87 | BCL2L1 (0.45) | GAARAB9AMAPTL3MBTL1ALDH1A1 | |
| SCHEMBL9574909 | 0.81 | HTT (0.44) | ARMAPTALDH1A1KMT2AMEN1 | |
| SCHEMBL8868444 | 0.80 | KDR (0.49) | NR3C1PGRARESR2GAA | |
| SCHEMBL9574745 | 0.79 | SMN1; SMN2 (0.39) | ARALDH1A1KMT2AMEN1LMNA | |
| SCHEMBL8869647 | 0.79 | PGR (0.50) | NR3C1PGRARESR2GAA | |
| SCHEMBL9574724 | 0.78 | PGR (0.50) | PGRALDH1A1KDM4EKMT2AMEN1 | |
| SCHEMBL9574705 | 0.76 | CACNA1B (0.46) | PGRRAB9AMAPTALDH1A1TDP1 | |
| SCHEMBL9574732 | 0.74 | SMN1; SMN2 (0.45) | RAB9AALDH1A1KDM4EKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0562512-A1 | Sulfonamido- and sulfonamidocarbonyl-pyridine-2-carboxamides and their pyridine-N-oxides, process for their preparation and their use as medicines | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-09-29 | — | — | EP | disclosed |