Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 5/20 | 0.43 |
| ▸ | BCHE | P06276 | 3/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.33 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9575560 | 0.88 | ACHE (0.40) | ACHEHDAC1HDAC2MEN1TSHR | |
| SCHEMBL9575530 | 0.85 | ACHE (0.43) | ACHEBCHEHDAC1HDAC2FLT3 | |
| SCHEMBL9575342 | 0.85 | ACHE (0.43) | ACHEBCHEHDAC1HDAC2FLT3 | |
| SCHEMBL9575441 | 0.85 | RPS6KA3 (0.35) | ACHEBRD4TSHR | |
| SCHEMBL9575539 | 0.80 | MEN1 (0.48) | ACHEHDAC1MEN1TSHRKMT2A | |
| SCHEMBL9575550 | 0.80 | ACHE (0.42) | ACHEHDAC1HDAC2MEN1TSHR | |
| SCHEMBL8896639 | 0.73 | ACHE (0.44) | ACHEBCHEHDAC1HDAC2MEN1 | |
| SCHEMBL10405793 | 0.73 | ACHE (0.44) | ACHEHDAC1HDAC2MEN1TSHR | |
| SCHEMBL8713036 | 0.72 | ACHE (0.47) | ACHEHDAC1HDAC2MEN1TSHR | |
| SCHEMBL9575361 | 0.72 | BCHE (0.48) | ACHEBCHEADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5225550-A | PROCESS FOR THE PREPARATION OF SUBSTITUTED ACYCLIC NUCLEOSIDES, AND INTERMEDIATES OCCURRING THEREIN | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-07-06 | — | — | US | disclosed |
| CN-1057652-A | A kind of acyclic nucleotide of replacement and method of related intermediates thereof of preparing | HOECHST AG (DE) | 1992-01-08 | — | — | CN | disclosed |