Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 4/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | USP5 | P45974 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.45 |
| ▸ | TYR | P14679 | 2/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.42 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.42 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.42 |
| ▸ | ALB | P02768 | 1/20 | 0.42 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | RARB | P10826 | 1/20 | 0.42 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9577333 | 0.87 | BRD4 (0.47) | CYP2C9CYP2D6PTGS2PTGS1LMNA | |
| SCHEMBL14511593 | 0.87 | PTGS2 (0.42) | CYP2C9CYP2D6HIF1APTGS2PTGS1 | |
| SCHEMBL9577440 | 0.84 | ESR1 (0.50) | CYP2C9CYP2D6PTGS2PTGS1LMNA | |
| SCHEMBL9577465 | 0.84 | ALOX5 (0.44) | CYP2C9PTGS2PTGS1LMNAAKR1C3 | |
| SCHEMBL7973447 | 0.84 | PTGS2 (0.52) | CYP2D6HIF1AKDM4EMAPK1PTGS2 | |
| SCHEMBL851630 | 0.84 | PTGS2 (0.52) | CYP2D6HIF1AKDM4EMAPK1PTGS2 | |
| SCHEMBL29273241 | 0.84 | PTGS2 (0.52) | CYP2D6HIF1AKDM4EMAPK1PTGS2 | |
| SCHEMBL9577279 | 0.83 | TSHR (0.50) | CYP2C9PTGS2TYRTSHRKMT2A | |
| SCHEMBL10443227 | 0.83 | GRM7 (0.44) | CYP2C9KDM4EPTGS2PTGS1LMNA | |
| SCHEMBL1290070 | 0.83 | CYP1A2 (0.47) | CYP2C9CYP2D6PTGS2PTGS1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0407588-B1 | PROCESS FOR PRODUCING 2-OXO-3-AROMATIC CARBOXYLIC ACID DERIVATIVES | SAGAMI CHEM RES (JP) | 1993-12-08 | — | — | EP | disclosed |
| US-5028738-A | Process for producing 2-oxo-3-aromatic carboxylic acid derivatives | SAGAMI CHEMICAL RESEARCH CENTER (JP) | 1991-07-02 | — | — | US | disclosed |
| EP-0407588-A1 | PROCESS FOR PRODUCING 2-OXO-3-AROMATIC CARBOXYLIC ACID DERIVATIVES | SAGAMI CHEMICAL RESEARCH CENTER (JP) | 1991-01-16 | — | — | EP | disclosed |
| EP-0386243-A1 | PLATINUM (II) COMPLEXES | SAGAMI CHEMICAL RESEARCH CENTER (JP) | 1990-09-12 | — | — | EP | disclosed |