Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.53 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.53 |
| ▸ | HCAR2 | Q8TDS4 | 4/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | THRB | P10828 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | TNKS | O95271 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.33 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL16099816 | 1.00 | TSHR (0.53) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL958116 | 1.00 | TSHR (0.53) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Maleic Acid SCHEMBL6544211 | 1.00 | TSHR (0.53) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL27903060 | 0.97 | TSHR (0.50) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Monomethyl Fumarate SCHEMBL28979771 | 0.82 | HCAR2 (0.68) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Monomethyl Fumarate SCHEMBL11141023 | 0.82 | HCAR2 (0.68) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Bicarbonate SCHEMBL6249355 | 0.81 | CA1 (0.39) | — | |
| Bicarbonate SCHEMBL7515371 | 0.81 | CA1 (0.39) | — | |
| Bicarbonate SCHEMBL9418217 | 0.81 | — | — | |
| Bicarbonate SCHEMBL283948 | 0.81 | CA1 (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11781021-B2 | Dicyclopentadiene modified ester oligomers useful in corrosion resistant coatings | PTT GLOBAL CHEMICAL PUBLIC COMPANY LIMITED (TH) | 2023-10-10 | — | — | US | disclosed |
| CN-109476773-B | Curable composition, cured product, and method for producing cured product | 株式会社艾迪科 | 2022-05-13 | — | — | CN | disclosed |
| CN-110869467-B | Composition, cured product, and method for producing cured product | 株式会社艾迪科 | 2022-05-10 | — | — | CN | disclosed |
| CN-108431139-B | Dicyclopentadiene modified ester oligomers useful in coating applications | PTT全球化学公众有限公司 | 2021-04-20 | — | — | CN | disclosed |
| EP-3649204-B1 | DICYCLOPENTADIENE MODIFIED ESTER OLIGOMERS USEFUL IN CORROSION RESISTANT COATINGS | PTT GLOBAL CHEMICAL PUBLIC CO LTD (TH) | 2021-03-24 | — | — | EP | disclosed |
| US-10815381-B2 | Dicyclopentadiene modified ester oligomers useful in coating applications | PTT GLOBAL CHEMICAL PUBLIC COMPANY LIMITED (TH) | 2020-10-27 | — | — | US | disclosed |
| US-20200239706-A1 | DICYCLOPENTADIENE MODIFIED ESTER OLIGOMERS USEFUL IN CORROSION RESISTANT COATINGS | PTT GLOBAL CHEMICAL PUBLIC COMPANY LIMITED (TH) | 2020-07-30 | — | — | US | disclosed |
| EP-3649204-A1 | DICYCLOPENTADIENE MODIFIED ESTER OLIGOMERS USEFUL IN CORROSION RESISTANT COATINGS | PTT Global Chemical Public Company Limited (TH) | 2020-05-13 | — | — | EP | disclosed |
| CN-110914375-A | Dicyclopentadiene-modified ester oligomers for corrosion-resistant coatings | PTT全球化学股份有限公司 | 2020-03-24 | — | — | CN | disclosed |
| WO-2019010006-A1 | DICYCLOPENTADIENE MODIFIED ESTER OLIGOMERS USEFUL IN CORROSION RESISTANT COATINGS | MYRIANT CORPORATION (US) | 2019-01-10 | — | — | WO | disclosed |
| WO-2017112680-A1 | DICYCLOPENTADIENE MODIFIED ESTER OLIGOMERS USEFUL IN COATING APPLICATIONS | MYRIANT CORPORATION (US) | 2017-06-29 | — | — | WO | disclosed |
| CN-102153726-B | Synthesis method of modified epoxy vinyl ester resin | HUACHANG POLYMER CO LTD OF ECUST | 2015-07-01 | — | — | CN | disclosed |
| CN-104072687-A | Epoxy vinyl ester resin compound catalytic synthesis technology | HUACHANG POLYMER CO LTD OF ECUST | 2014-10-01 | — | — | CN | disclosed |
| CN-102153726-A | Synthesis method of modified epoxy vinyl ester resin | HUACHANG POLYMER CO LTD OF ECUST | 2011-08-17 | — | — | CN | disclosed |
| EP-0549923-A2 | Curable composition, process for its preparation and its use for fixing wound-up materials | Herberts Gesellschaft mit beschränkter Haftung (DE) | 1993-07-07 | — | — | EP | disclosed |
| US-5084494-A | Polyester resin and reinforcement composite materials | MCDOUGAL JOHN R (US) | 1992-01-28 | — | — | US | disclosed |
| EP-0124604-B1 | PROCESS FOR THE MANUFACTURE OF PRODUCTS FROM REINFORCED POLYESTER RESINS | Thermoset Services, Inc. (US) | 1987-03-11 | — | — | EP | disclosed |
| US-4647418-A | Process for the manufacture of products from reinforced polyester | DOUGHERTY, MICHAEL, J. | 1987-03-03 | — | — | US | disclosed |
| US-4624814-A | Process for the manufacture of products from reinforced polyester resins | DOUGHERTY, MICHAEL, J. | 1986-11-25 | — | — | US | disclosed |
| US-4524043-A | Process for the manufacture of products from reinforced polyester resins | DOUGHERTY, MICHAEL, J. | 1985-06-18 | — | — | US | disclosed |