Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.53 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.53 |
| ▸ | HCAR2 | Q8TDS4 | 4/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | THRB | P10828 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | TNKS | O95271 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.33 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL16099816 | 1.00 | TSHR (0.53) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL958116 | 1.00 | TSHR (0.53) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Maleic Acid SCHEMBL9580936 | 1.00 | TSHR (0.53) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL27903060 | 0.97 | TSHR (0.50) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Monomethyl Fumarate SCHEMBL28979771 | 0.82 | HCAR2 (0.68) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Monomethyl Fumarate SCHEMBL11141023 | 0.82 | HCAR2 (0.68) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Bicarbonate SCHEMBL6249355 | 0.81 | CA1 (0.39) | — | |
| Bicarbonate SCHEMBL7515371 | 0.81 | CA1 (0.39) | — | |
| Bicarbonate SCHEMBL9418217 | 0.81 | — | — | |
| Bicarbonate SCHEMBL283948 | 0.81 | CA1 (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118725422-A | Carcass rubber composition for reducing carbon black use, preparation method thereof and tire | 中策橡胶集团股份有限公司 | 2024-10-01 | — | — | CN | claimed |
| CN-118599194-A | Tire transition layer rubber composition for reducing carbon black use, preparation method thereof and tire | 中策橡胶集团股份有限公司 | 2024-09-06 | — | — | CN | claimed |
| CN-114478840-B | Functionalized reversion liquid rubber and preparation method thereof | 杭州中策橡胶循环科技有限公司 | 2022-09-06 | — | — | CN | claimed |
| CN-114478840-A | Functionalized reversion liquid rubber and preparation method thereof | 杭州中策橡胶循环科技有限公司 | 2022-05-13 | — | — | CN | claimed |
| EP-2976380-B1 | DIENE/DIENOPHILE COUPLES AND THERMOSETTING RESIN COMPOSITIONS HAVING REWORKABILITY | Henkel IP & Holding GmbH (DE) | 2018-10-10 | — | — | EP | claimed |
| US-20180155588-A1 | DIENE/DIENOPHILE COUPLES AND THERMOSETTING RESIN COMPOSITIONS HAVING REWORKABILITY | HENKEL AG & CO. KGAA (DE) | 2018-06-07 | — | — | US | claimed |
| US-9938437-B2 | Diene/dienophile couples and thermosetting resin compositions having reworkability | Henkel IP & Holding GmbH (DE) | 2018-04-10 | — | — | US | claimed |
| EP-2976380-A1 | DIENE/DIENOPHILE COUPLES AND THERMOSETTING RESIN COMPOSITIONS HAVING REWORKABILITY | Henkel IP & Holding GmbH (DE) | 2016-01-27 | — | — | EP | claimed |
| US-20160002510-A1 | DIENE/DIENOPHILE COUPLES AND THERMOSETTING RESIN COMPOSITIONS HAVING REWORKABILITY | HENKEL AG & CO. KGAA (DE) | 2016-01-07 | — | — | US | claimed |
| WO-2014153513-A1 | DIENE/DIENOPHILE COUPLES AND THERMOSETTING RESIN COMPOSITIONS HAVING REWORKABILITY | Henkel IP & Holding GmbH (DE) | 2014-09-25 | — | — | WO | claimed |
| CN-118725422-A | Carcass rubber composition for reducing carbon black use, preparation method thereof and tire | 中策橡胶集团股份有限公司 | 2024-10-01 | — | — | CN | disclosed |
| CN-118599194-A | Tire transition layer rubber composition for reducing carbon black use, preparation method thereof and tire | 中策橡胶集团股份有限公司 | 2024-09-06 | — | — | CN | disclosed |
| CN-114478840-B | Functionalized reversion liquid rubber and preparation method thereof | 杭州中策橡胶循环科技有限公司 | 2022-09-06 | — | — | CN | disclosed |
| CN-114478840-A | Functionalized reversion liquid rubber and preparation method thereof | 杭州中策橡胶循环科技有限公司 | 2022-05-13 | — | — | CN | disclosed |
| CN-107365400-B | A kind of synthetic method of styrene-dicyclopentadiene monomaleate copolymer | 中国科学院新疆理化技术研究所 | 2019-11-19 | — | — | CN | disclosed |
| WO-2014153513-A1 | DIENE/DIENOPHILE COUPLES AND THERMOSETTING RESIN COMPOSITIONS HAVING REWORKABILITY | Henkel IP & Holding GmbH (DE) | 2014-09-25 | — | — | WO | disclosed |
| CN-102407633-A | Combined Lamination Body | JSP K K | 2012-04-11 | — | — | CN | disclosed |
| US-20040116643-A1 | Composite resin and use thereof | TOYO INK MFG. CO., LTD. (JP) | 2004-06-17 | — | — | US | disclosed |
| EP-1375558-A1 | COMPOSITE RESIN AND USE THEREOF | TOYO INK MFG. CO., LTD. (JP) | 2004-01-02 | — | — | EP | disclosed |
| US-4105607-A | COPOLYMER OF DICYCLOPENTADIENE AND AN OLEFINICALLY UNSATURATED CARBOXYLIC ACID OR ALCOHOL | HOECHST AKTIENGESELLSCHAFT (DE) | 1978-08-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160002510-A1 | DIENE/DIENOPHILE COUPLES AND THERMOSETTING RESIN COMPOSITIONS HAVING REWORKABILITY | GCN1, GSS, LSS | TSHR 4372/4885TP53 4004/4885EGLN1 1905/4885 |
| US-20180155588-A1 | DIENE/DIENOPHILE COUPLES AND THERMOSETTING RESIN COMPOSITIONS HAVING REWORKABILITY | GCN1, GSS, LSS | TSHR 4372/4885TP53 4004/4885EGLN1 1905/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.