Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A known ✓ | Q03164 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 3/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.53 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.53 |
| ▸ | HCAR2 | Q8TDS4 | 4/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | THRB | P10828 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | TNKS | O95271 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.33 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL16099816 | 1.00 | TSHR (0.53) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Maleic Acid SCHEMBL9580936 | 1.00 | TSHR (0.53) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Maleic Acid SCHEMBL6544211 | 1.00 | TSHR (0.53) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL27903060 | 0.97 | TSHR (0.50) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Monomethyl Fumarate SCHEMBL28979771 | 0.82 | HCAR2 (0.68) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Monomethyl Fumarate SCHEMBL11141023 | 0.82 | HCAR2 (0.68) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Bicarbonate SCHEMBL6249355 | 0.81 | CA1 (0.39) | — | |
| Bicarbonate SCHEMBL7515371 | 0.81 | CA1 (0.39) | — | |
| Bicarbonate SCHEMBL9418217 | 0.81 | — | — | |
| Bicarbonate SCHEMBL283948 | 0.81 | CA1 (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 144 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118725422-A | Carcass rubber composition for reducing carbon black use, preparation method thereof and tire | 中策橡胶集团股份有限公司 | 2024-10-01 | — | — | CN | claimed |
| CN-118599194-A | Tire transition layer rubber composition for reducing carbon black use, preparation method thereof and tire | 中策橡胶集团股份有限公司 | 2024-09-06 | — | — | CN | claimed |
| CN-117164953-A | Low-temperature desulfurization oilless high-molecular-weight reclaimed rubber, preparation method and application thereof in tire carcass | 中策橡胶集团股份有限公司 | 2023-12-05 | — | — | CN | claimed |
| CN-114478840-B | Functionalized reversion liquid rubber and preparation method thereof | 杭州中策橡胶循环科技有限公司 | 2022-09-06 | — | — | CN | claimed |
| CN-114478840-A | Functionalized reversion liquid rubber and preparation method thereof | 杭州中策橡胶循环科技有限公司 | 2022-05-13 | — | — | CN | claimed |
| CN-112029437-B | Acrylic pressure-sensitive adhesive tape and preparation method and application thereof | 安徽亥博新材料有限公司 | 2022-02-11 | — | — | CN | claimed |
| CN-112029437-A | Acrylic pressure-sensitive adhesive tape and preparation method and application thereof | 安徽亥博新材料有限公司 | 2020-12-04 | — | — | CN | claimed |
| CN-110591295-A | Preparation method of photosensitive resin for 3D printing | 刘乾坤 | 2019-12-20 | — | — | CN | claimed |
| CN-109094166-A | A kind of preparation method of High Tg CCL | 山东金宝电子股份有限公司 | 2018-12-28 | — | — | CN | claimed |
| CN-102153726-B | Synthesis method of modified epoxy vinyl ester resin | HUACHANG POLYMER CO LTD OF ECUST | 2015-07-01 | — | — | CN | claimed |
| CN-102115534-B | Dicyclopentadiene type unsaturated polyester modified by tung oil, and preparation method and application thereof | INST CHEM IND FOREST PROD CAF | 2013-06-05 | — | — | CN | claimed |
| CN-102153726-A | Synthesis method of modified epoxy vinyl ester resin | HUACHANG POLYMER CO LTD OF ECUST | 2011-08-17 | — | — | CN | claimed |
| JP-8085713-A | — | — | None | — | — | JP | disclosed |
| JP-7238255-A | — | — | None | — | — | JP | disclosed |
| JP-53129282-A | — | — | None | — | — | JP | disclosed |
| JP-4132732-A | — | — | None | — | — | JP | disclosed |
| US-4524043-A | Process for the manufacture of products from reinforced polyester resins | DOUGHERTY, MICHAEL, J. | 1985-06-18 | — | — | US | disclosed |
| US-4224430-A | ACRYLIC COPOLYESTER; MOLDING MATERIALS OF EXCELLENT WATER AND CHEMICAL RESISTANCE | HITACHI CHEMICAL COMPANY, LTD. (JP) | 1980-09-23 | — | — | US | disclosed |
| JP-S53129282-A | CURABLE RESIN COMPOSITION | HITACHI CHEM CO LTD | 1978-11-11 | — | — | JP | disclosed |
| US-4100120-A | COATING FILMS WHICH HAVE EXCELLENT RESISTANCE TO BLOCKING, SOLVENTS, AND STAINS, HARDNESS, GLOSS, FLEXIBILITY | HITACHI CHEMICAL COMPANY, LTD. (JP) | 1978-07-11 | — | — | US | disclosed |