Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 1/20 | 0.57 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.51 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.51 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.51 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.51 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.51 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11017624 | 0.96 | HTR7 (0.63) | HTR7ADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL9582316 | 0.92 | HTR7 (0.67) | HTR7ADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL9582259 | 0.92 | KMT2A (0.54) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL9581620 | 0.91 | HTR7 (0.51) | HTR7ADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL9582681 | 0.91 | HTR7 (0.53) | HTR7ADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL11357559 | 0.85 | DRD2 (0.54) | — | |
| SCHEMBL9582467 | 0.85 | DRD2 (0.47) | HTR7ADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL9582106 | 0.85 | KDM4E (0.48) | — | |
| SCHEMBL9581356 | 0.84 | KDM4E (0.64) | HTR7 | |
| SCHEMBL9582089 | 0.84 | KDM4E (0.48) | HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5256673-A | Indole-3-yl-A-tetrahydropyridyl or piperidyl compounds | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1993-10-26 | — | — | US | disclosed |
| EP-0144012-B1 | INDOLE DERIVATIVES | MERCK PATENT GmbH (DE) | 1988-03-16 | — | — | EP | disclosed |