Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | HTR7 | P34969 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | HTR1D | P28221 | 1/20 | 0.42 |
| ▸ | HTR1B | P28222 | 1/20 | 0.42 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.42 |
| ▸ | HAT1 | O14929 | 1/20 | 0.42 |
| ▸ | EP300 | Q09472 | 1/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.41 |
| ▸ | CCR3 | P51677 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9582267 | 0.93 | HTR7 (0.54) | DRD2DRD4DRD3HTR7HTR1D | |
| SCHEMBL10648783 | 0.93 | DRD2 (0.49) | DRD2DRD4DRD3SIGMAR1AVPR1A | |
| SCHEMBL9582120 | 0.92 | HTR1D (0.42) | DRD2DRD4DRD3HTR7HTR1D | |
| SCHEMBL9582464 | 0.91 | DRD2 (0.44) | DRD2DRD4DRD3HTR7HTR1D | |
| SCHEMBL10650001 | 0.85 | DRD2 (0.49) | DRD2DRD4DRD3HTR7SIGMAR1 | |
| SCHEMBL9581369 | 0.85 | HTR7 (0.57) | HTR7ADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL10648787 | 0.84 | DRD2 (0.47) | DRD2DRD4DRD3SIGMAR1AVPR1A | |
| SCHEMBL9582584 | 0.84 | HTR7 (0.47) | HTR7HTR1DHTR1BADRA2AADRA2B | |
| SCHEMBL9582767 | 0.84 | HTR7 (0.49) | DRD2HTR7HTR1DHTR1BADRA2A | |
| SCHEMBL10412923 | 0.84 | SLC18A3 (0.47) | DRD2DRD4DRD3AVPR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5256673-A | Indole-3-yl-A-tetrahydropyridyl or piperidyl compounds | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1993-10-26 | — | — | US | disclosed |
| EP-0144012-B1 | INDOLE DERIVATIVES | MERCK PATENT GmbH (DE) | 1988-03-16 | — | — | EP | disclosed |
| EP-0144012-A1 | Indole derivatives | MERCK PATENT GmbH (DE) | 1985-06-12 | — | — | EP | disclosed |