Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.44 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
| ▸ | HTR1D | P28221 | 2/20 | 0.42 |
| ▸ | HTR1B | P28222 | 2/20 | 0.42 |
| ▸ | DRD3 | P35462 | 3/20 | 0.39 |
| ▸ | CCR3 | P51677 | 1/20 | 0.39 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.38 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 2/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | DRD1 | P21728 | 1/20 | 0.38 |
| ▸ | DRD5 | P21918 | 1/20 | 0.38 |
| ▸ | HAT1 | O14929 | 1/20 | 0.38 |
| ▸ | EP300 | Q09472 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9582767 | 0.93 | HTR7 (0.49) | DRD2HTR7HTR1DHTR1BHTR1A | |
| SCHEMBL9582467 | 0.91 | DRD2 (0.47) | DRD2HTR7HTR1DHTR1BDRD3 | |
| SCHEMBL9582397 | 0.91 | DRD3 (0.47) | DRD2HTR1DHTR1BDRD3DRD4 | |
| SCHEMBL9582120 | 0.90 | HTR1D (0.42) | DRD2HTR7HTR1DHTR1BDRD3 | |
| SCHEMBL9582681 | 0.86 | HTR7 (0.53) | HTR7 | |
| SCHEMBL10648649 | 0.85 | DRD2 (0.43) | DRD2DRD3DRD4HTR1ADRD1 | |
| SCHEMBL9581681 | 0.84 | SIGMAR1 (0.47) | DRD2HTR7DRD3DRD4 | |
| SCHEMBL9582267 | 0.84 | HTR7 (0.54) | DRD2HTR7HTR1DHTR1BDRD3 | |
| SCHEMBL10648783 | 0.84 | DRD2 (0.49) | DRD2DRD3CCR3DRD4 | |
| SCHEMBL9581294 | 0.83 | TSHR (0.34) | DRD2HTR7HTR1DHTR1BHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5256673-A | Indole-3-yl-A-tetrahydropyridyl or piperidyl compounds | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1993-10-26 | — | — | US | disclosed |
| EP-0144012-A1 | Indole derivatives | MERCK PATENT GmbH (DE) | 1985-06-12 | — | — | EP | disclosed |