Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 7/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.59 |
| ▸ | TSHR | P16473 | 2/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.59 |
| ▸ | BCHE | P06276 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | GLA | P06280 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | CASP1 | P29466 | 2/20 | 0.46 |
| ▸ | CASP7 | P55210 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | NQO2 | P16083 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8781795 | 0.78 | ACHE (0.62) | ACHEALDH1A1KCNH2CYP1A2TSHR | |
| SCHEMBL9585106 | 0.78 | CTSD (0.39) | ACHEALDH1A1KCNH2CYP1A2TSHR | |
| Velnacrine SCHEMBL194467 | 0.75 | CYP1A2 (1.00) | ACHEALDH1A1KCNH2CYP1A2TSHR | |
| SCHEMBL9584702 | 0.73 | ACHE (0.82) | ACHEALDH1A1KCNH2CYP1A2TSHR | |
| SCHEMBL9215322 | 0.71 | ACHE (1.00) | ACHEALDH1A1KCNH2CYP1A2TSHR | |
| SCHEMBL5083430 | 0.69 | ACHE (0.66) | ACHEALDH1A1KCNH2CYP1A2TSHR | |
| SCHEMBL8781948 | 0.69 | ACHE (0.62) | ACHEALDH1A1KCNH2CYP1A2TSHR | |
| Velnacrine SCHEMBL50846 | 0.68 | TSHR (0.83) | ACHEALDH1A1KCNH2CYP1A2TSHR | |
| Velnacrine SCHEMBL637476 | 0.68 | TSHR (0.83) | ACHEALDH1A1KCNH2CYP1A2TSHR | |
| Velnacrine SCHEMBL7193446 | 0.68 | TSHR (0.83) | ACHEALDH1A1KCNH2CYP1A2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5202440-A | Certain 9-amino-2-(or 4)-oxa 1,2,3,4-tetrahydro- or 1,2,3,4,5,6,7,8-octahydro-acridines | PFIZER INC. (US) | 1993-04-13 | — | — | US | disclosed |
| EP-0311303-A2 | 4-aminopyridine derivatives | PFIZER INC. (US) | 1989-04-12 | — | — | EP | disclosed |
| WO-1989002740-A1 | 4-AMINOPYRIDINE DERIVATIVES | PFIZER INC. (US) | 1989-04-06 | — | — | WO | disclosed |