Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | C1S | P09871 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | CTSL | P07711 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | CTSB | P07858 | 1/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28672324 | 0.81 | MEN1 (0.53) | MEN1CYP1A2CYP2C19KMT2AKDM4E | |
| SCHEMBL30321417 | 0.81 | MEN1 (0.53) | MEN1CYP1A2CYP2C19KMT2AKDM4E | |
| SCHEMBL9586306 | 0.80 | ELANE (0.45) | KMT2AKDM4ELMNAPARP1CTSL | |
| SCHEMBL14210113 | 0.79 | C1S (0.55) | KDM4EMAPK1LMNATSHRC1S | |
| SCHEMBL7527945 | 0.79 | CES2 (0.53) | MEN1KMT2AMAPK1LMNATSHR | |
| SCHEMBL11444418 | 0.79 | ALDH1A1 (0.47) | MEN1CYP1A2CYP2C19KMT2AKDM4E | |
| SCHEMBL1641519 | 0.78 | ALDH1A1 (0.47) | MEN1KMT2ALMNATSHRSMN1; SMN2 | |
| SCHEMBL9041640 | 0.78 | ALDH1A1 (0.47) | MEN1KMT2ALMNATSHRSMN1; SMN2 | |
| SCHEMBL245137 | 0.78 | KDM4E (0.65) | KMT2AKDM4EMAPK1LMNATSHR | |
| Hydrochloric Acid SCHEMBL4822185 | 0.78 | C1S (0.53) | KDM4EMAPK1LMNATSHRC1S |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5204482-A | Ethylenediamine monoamide heteroaryl derivatives | HOFFMAN-LAROCHE INC. (US) | 1993-04-20 | — | — | US | disclosed |
| US-5011849-A | Monoamine oxidase inhibitors | HOFFMANN-LA ROCHE INC. (US) | 1991-04-30 | — | — | US | disclosed |