SCHEMBL245137

SCHEMBL245137

CCOC(=O)c1cccc(Br)c1

nearest known ligand 0.65

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.65
MAPK1 P28482 1/20 0.65
TSHR P16473 2/20 0.63
LMNA P02545 1/20 0.63
CYP4F2 P78329 1/20 0.58
CYP4A11 Q02928 1/20 0.58
SMN1; SMN2 Q16637 1/20 0.57
CA12 O43570 1/20 0.56
CA1 P00915 1/20 0.56
CA2 P00918 1/20 0.56
CA7 P43166 1/20 0.56
CA9 Q16790 1/20 0.56
CA14 Q9ULX7 1/20 0.56
ALDH1A1 P00352 1/20 0.54
KMT2A Q03164 1/20 0.54
RXFP1 Q9HBX9 1/20 0.54
MEP1B Q16820 1/20 0.54
NPC1 O15118 1/20 0.53
RAB9A P51151 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29627840 1.00 KDM4E (0.65) KDM4EMAPK1TSHRLMNACYP4F2
SCHEMBL6225292 0.92 KDM4E (0.57) KDM4EMAPK1TSHRLMNACYP4F2
SCHEMBL7472353 0.91 KDM4E (0.56) KDM4EMAPK1TSHRLMNACYP4F2
SCHEMBL110276 0.88 CYP4F2 (0.65) KDM4ETSHRLMNACYP4F2CYP4A11
SCHEMBL28376879 0.86 CYP4F2 (0.63) KDM4ETSHRCYP4F2CYP4A11SMN1; SMN2
SCHEMBL29427226 0.86 CYP4F2 (0.63) KDM4ETSHRCYP4F2CYP4A11SMN1; SMN2
SCHEMBL15344554 0.86 LMNA (0.68) KDM4EMAPK1TSHRLMNASMN1; SMN2
SCHEMBL514887 0.84 KDM4E (0.60) KDM4EMAPK1TSHRLMNASMN1; SMN2
SCHEMBL2332900 0.84 MAPK1 (0.59) KDM4EMAPK1TSHRLMNASMN1; SMN2
SCHEMBL570920 0.83 TDP1 (0.60) TSHRCYP4F2CYP4A11CA12CA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 660 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113980117-B Fenpyroximate antigen and preparation method and application thereof 西南大学 2024-07-12 CN claimed
CN-117820460-A Methoxypiperidine ethyl antigen and preparation method and application thereof 西南大学 2024-04-05 CN claimed
CN-108484541-B Synthesis method of 5-formyl furan-2-ethyl nitrobenzoate 济南大学 2022-06-07 CN claimed
CN-114560834-A Spirodiclofen hapten, antigen and antibody as well as preparation method and application thereof 西南大学 2022-05-31 CN claimed
CN-113980117-A Fenpyroximate antigen and preparation method and application thereof 西南大学 2022-01-28 CN claimed
CN-108484541-A A kind of synthetic method of 5- formylfurans -2- ethyl nitrobenzoates 济南大学 2018-09-04 CN claimed
CN-102834420-B Internal and external donor compounds for olefin polymerization catalysts ii BASF CORP. (US) 2014-10-22 CN claimed
US-8569195-B2 Internal and external donor compounds for olefin polymerization catalysts II BASF CORPORATION (US) 2013-10-29 US claimed
CN-102834420-A Internal and external donor compounds for olefin polymerization catalysts ii BASF CORP 2012-12-19 CN claimed
US-12637440-B2 Amide derivative useful as diacylglycerol acyltransferase 2 inhibitor, and use thereof LG CHEM, LTD. (KR) 2026-05-26 US disclosed
US-12637454-B2 Heterocyclic monoacylglycerol lipase (MAGL) inhibitors HOFFMANN-LA ROCHE INC. (US) 2026-05-26 US disclosed
US-12637436-B2 Metabotropic glutamate receptor negative allosteric modulators (NAMs) and uses thereof Sanford Burnham Prebys Medical Discovery Institute (US) 2026-05-26 US disclosed
US-20260027106-A1 PRMT5 INHIBITORS AND USES THEREOF Epizyme, Inc. 2026-01-29 US disclosed
EP-3745105-B1 TEMPERATURE DETECTION LABEL AND ARTICLE MANAGEMENT DEVICE USING SAME HITACHI LTD (JP) 2025-08-27 EP disclosed
WO-1993008799-A1 ENDOTHELIN RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM CORPORATION (US) 1993-05-13 WO disclosed
EP-0501578-A1 Pyranylphenyl hydroxyalkylnaphthoic acids as inhibitors of leukotriene biosynthesis MERCK FROSST CANADA INC. (CA) 1992-09-02 EP disclosed
EP-0501579-A1 Naphthalene lactones as inhibitors of leukotriene biosynthesis MERCK FROSST CANADA INC. (CA) 1992-09-02 EP disclosed
WO-1989006125-A1 4-ARALKYL-5-SUBSTITUTED-1,2,4-TRIAZOLE-5-THIOLS SMITHKLINE BECKMAN CORPORATION (US) 1989-07-13 WO disclosed
EP-0323737-A1 4-Aralkyl-5-substituted-1,2,4-triazole-5-thiols SMITHKLINE BEECHAM CORPORATION (US) 1989-07-12 EP disclosed
CN-1030074-A LEUKOTRIENE ANTAGONISTS SMITHKLINE BECKMAN CORP (US) 1989-01-04 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260027106-A1 PRMT5 INHIBITORS AND USES THEREOF PRMT5, PRMT1, PRMT3 KDM4E 390/4885MAPK1 1870/4885TSHR 315/4885
US-12637454-B2 Heterocyclic monoacylglycerol lipase (MAGL) inhibitors MGLL, LIPA, LIPC KDM4E 1950/4885MAPK1 1708/4885TSHR 2474/4885
US-12637440-B2 Amide derivative useful as diacylglycerol acyltransferase 2 inhibitor, and use thereof DGAT2, DGAT1, DLAT KDM4E 3064/4885MAPK1 2480/4885TSHR 2348/4885
US-12637436-B2 Metabotropic glutamate receptor negative allosteric modulators (NAMs) and uses thereof GRM3, GRM2, GRM1 KDM4E 1949/4885MAPK1 1372/4885TSHR 316/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.