Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | PLK1 | P53350 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 6/20 | 0.36 |
| ▸ | NPC1 | O15118 | 5/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | STAT1 | P42224 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6522396 | 0.87 | SMN1; SMN2 (0.56) | SMN1; SMN2MEN1KMT2AGAAALDH1A1 | |
| SCHEMBL9587118 | 0.83 | CASP1 (0.56) | SMN1; SMN2MEN1KMT2AGAAALDH1A1 | |
| SCHEMBL7358766 | 0.80 | MEN1 (0.50) | SMN1; SMN2MEN1KMT2AGAAALDH1A1 | |
| SCHEMBL1895234 | 0.79 | SMN1; SMN2 (0.42) | SMN1; SMN2MEN1KMT2AGAAALDH1A1 | |
| SCHEMBL1274082 | 0.78 | KMT2A (0.43) | SMN1; SMN2MEN1KMT2AGAAALDH1A1 | |
| SCHEMBL9586863 | 0.77 | MAPT (0.47) | SMN1; SMN2MEN1KMT2AGAAALDH1A1 | |
| SCHEMBL19464224 | 0.76 | KMT2A (0.53) | SMN1; SMN2MEN1KMT2AGAAALDH1A1 | |
| SCHEMBL20723058 | 0.76 | CES2 (0.42) | SMN1; SMN2MEN1KMT2AGAAALDH1A1 | |
| SCHEMBL9715487 | 0.75 | ALDH1A1 (0.41) | SMN1; SMN2MEN1KMT2AGAAALDH1A1 | |
| SCHEMBL15268526 | 0.74 | CTSS (0.41) | SMN1; SMN2MEN1KMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5204482-A | Ethylenediamine monoamide heteroaryl derivatives | HOFFMAN-LAROCHE INC. (US) | 1993-04-20 | — | — | US | disclosed |
| US-5011849-A | Monoamine oxidase inhibitors | HOFFMANN-LA ROCHE INC. (US) | 1991-04-30 | — | — | US | disclosed |