Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 6/20 | 0.38 |
| ▸ | ITGB3 | P05106 | 6/20 | 0.38 |
| ▸ | ITGA2B | P08514 | 6/20 | 0.38 |
| ▸ | F2 | P00734 | 6/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 1/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.34 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7350849 | 0.91 | CYP3A4 (0.41) | F10F2CYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL7348843 | 0.84 | CYP3A4 (0.37) | F10ITGB3ITGA2BF2CYP3A4 | |
| SCHEMBL7343775 | 0.79 | CYP11B2 (0.40) | F10RORCGABRG2GABRB3GABRA5 | |
| SCHEMBL9589587 | 0.78 | SLC9A1 (0.43) | CYP2C19ALDH1A1TSHR | |
| SCHEMBL9589608 | 0.76 | MEN1 (0.32) | F10F2ALDH1A1TSHR | |
| SCHEMBL7350852 | 0.74 | MEN1 (0.32) | CYP3A4CYP2C19 | |
| SCHEMBL7342699 | 0.72 | USP30 (0.46) | ALDH1A1TSHR | |
| SCHEMBL7342609 | 0.72 | ALDH1A1 (0.41) | CYP3A4CYP2C19ALDH1A1L3MBTL1TSHR | |
| SCHEMBL7412460 | 0.72 | MAPT (0.35) | ALDH1A1 | |
| SCHEMBL7341558 | 0.70 | ALDH1A1 (0.44) | CYP3A4CYP2C19ALDH1A1L3MBTL1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5221742-A | PROCESS FOR THE PREPARATION OF 6-(3,4-DIHYDRO-3-OXO-1,4(2H)-BENZOXAZIN-7-YL)-2,3,4,5-TETRAHYDROPYRIDAZIN-3-ONES | ORTHO PHARMACEUTICAL CORPORATION (US) | 1993-06-22 | — | — | US | disclosed |
| WO-1992011256-A1 | PROCESS FOR THE PREPARATION OF BENZOXAZINYLTETRAHYDROPYRIDAZINES | ORTHO PHARMACEUTICAL CORPORATION (US) | 1992-07-09 | — | — | WO | disclosed |