Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.38 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9590924 | 0.95 | AGTR2 (0.38) | AGTR1AGTR2 | |
| SCHEMBL9592923 | 0.90 | AGTR1 (0.41) | AGTR1AGTR2 | |
| SCHEMBL9592014 | 0.90 | GSK3B (0.46) | AGTR1AGTR2 | |
| SCHEMBL9591379 | 0.89 | AGTR2 (0.41) | AGTR1AGTR2 | |
| SCHEMBL9592120 | 0.89 | AGTR1 (0.38) | AGTR1AGTR2 | |
| SCHEMBL9591498 | 0.89 | AGTR1 (0.43) | AGTR1AGTR2 | |
| SCHEMBL9592770 | 0.88 | AGTR1 (0.39) | PDE4APDE4BPDE4CPDE4DAGTR1 | |
| SCHEMBL9592109 | 0.87 | AGTR1 (0.37) | AGTR1AGTR2 | |
| SCHEMBL9592290 | 0.87 | — | — | |
| SCHEMBL9592968 | 0.86 | AGTR1 (0.37) | AGTR1AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5264439-A | Quinazolinone, triazolinone and pyrimidinone angiotensin II antagonists incorporating a substituted benzyl element | MERCK & CO., INC. (US) | 1993-11-23 | — | — | US | disclosed |