Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | CPB2 | Q96IY4 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | PDE2A | O00408 | 1/20 | 0.31 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.31 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.31 |
| ▸ | PDE4A | P27815 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.31 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.30 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31265576 | 0.85 | PDE3B (0.33) | PDE2APDE3BPDE3A | |
| SCHEMBL9570473 | 0.81 | PDE3B (0.34) | CPB2PDE2APDE3BPDE3AHTR2A | |
| SCHEMBL9570261 | 0.78 | CPB2 (0.33) | CPB2PDE2APDE3BPDE3A | |
| SCHEMBL31265577 | 0.77 | PDE3B (0.33) | PDE2APDE3BPDE3A | |
| SCHEMBL20536635 | 0.76 | NPC1 (0.45) | LMNAHTTCPB2NPC1RAB9A | |
| SCHEMBL22317590 | 0.75 | LMNA (0.41) | ADORA2ALMNAHTTCPB2NPC1 | |
| SCHEMBL20536189 | 0.73 | MEN1 (0.43) | ADORA2ALMNAHTTCPB2NPC1 | |
| SCHEMBL11845875 | 0.70 | CYP11B2 (0.47) | LMNAHTT | |
| SCHEMBL2402912 | 0.70 | DRD4 (0.41) | NPC1RAB9APDE2APDE3BPDE3A | |
| SCHEMBL6967545 | 0.69 | TSHR (0.51) | LMNAHTTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5270322-A | Imidazo[1,2-a]pyridines, pharmaceutical compositions containing these compounds and processes for preparing them | DR. KARL THOMAE GMBH (DE) | 1993-12-14 | — | — | US | disclosed |