Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.40 |
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 4/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | GLA | P06280 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.37 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9425711 | 0.99 | ADORA1 (0.43) | ADORA1KDM4EALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL11555201 | 0.84 | ITGB3 (0.38) | ADORA1KDM4EALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL9426273 | 0.81 | PNMT (0.40) | ADORA1KDM4EALDH1A1MAPTHPGD | |
| Hydrochloric Acid SCHEMBL9426239 | 0.79 | ADORA1 (0.46) | ADORA1KDM4EALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL9722794 | 0.78 | ALDH1A1 (0.50) | KDM4EALDH1A1MAPTSMN1; SMN2NPC1 | |
| SCHEMBL7790171 | 0.73 | ADORA1 (0.45) | ADORA1MAPTHSD17B10KMT2ACHRM3 | |
| SCHEMBL7796179 | 0.73 | ADORA1 (0.45) | ADORA1KDM4EALDH1A1MAPTHSD17B10 | |
| SCHEMBL22392265 | 0.72 | ALDH1A1 (0.46) | ADORA1KDM4EALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL29676767 | 0.71 | PNMT (0.45) | ADORA1KDM4EALDH1A1MAPTNPC1 | |
| Hydrochloric Acid SCHEMBL10859701 | 0.71 | ADORA1 (0.60) | ADORA1KDM4EALDH1A1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-5339272-A | — | — | None | — | — | JP | disclosed |
| CN-113453762-B | Pentacyclic heterocyclic compounds | 卫材R&D管理有限公司 | 2024-06-07 | — | — | CN | disclosed |
| US-11358972-B2 | Pentacyclic heterocycles | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2022-06-14 | — | — | US | disclosed |
| US-11358972-B2 | Pentacyclic heterocycles | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2022-06-14 | — | — | US | disclosed |
| EP-3936190-A1 | PENTACYCLIC HETEROCYCLIC COMPOUND | Eisai R&D Management Co., Ltd. (JP) | 2022-01-12 | — | — | EP | disclosed |
| EP-3936190-A1 | PENTACYCLIC HETEROCYCLIC COMPOUND | Eisai R&D Management Co., Ltd. (JP) | 2022-01-12 | — | — | EP | disclosed |
| US-20200283452-A1 | PENTACYCLIC HETEROCYCLES | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2020-09-10 | — | — | US | disclosed |
| US-20200283452-A1 | PENTACYCLIC HETEROCYCLES | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2020-09-10 | — | — | US | disclosed |
| JP-H05339272-A | 3-AMINO-4,5,6,7-TETRAHYDROTHIENO(3,2-C)PYRIDINE-2-CARBOXYLIC ACID DERVIATIVE AND ITS PRODUCLTION | FUJI PHOTO FILM CO LTD | 1993-12-21 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11358972-B2 | Pentacyclic heterocycles | CYP2C19, CYP2C18, XDH | ADORA1 1600/4885KDM4E 4151/4885ALDH1A1 352/4885 |
| US-20200283452-A1 | PENTACYCLIC HETEROCYCLES | CYP2C19, CYP2C18, XDH | ADORA1 1600/4885KDM4E 4151/4885ALDH1A1 352/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.