SCHEMBL9601849

SCHEMBL9601849

C=CCOC(=O)c1ccccc1NCC(=O)O

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 1/20 0.64
ALDH1A1 P00352 7/20 0.56
HSD17B10 Q99714 3/20 0.56
TSHR P16473 3/20 0.56
KDM4E B2RXH2 5/20 0.43
AGTR1 P30556 1/20 0.43
RAB9A P51151 1/20 0.43
GLA P06280 1/20 0.42
KMT2A Q03164 3/20 0.42
MEN1 O00255 2/20 0.42
NPC1 O15118 1/20 0.42
HPGD P15428 1/20 0.41
LIG1 P18858 1/20 0.40
CYP1A2 P05177 1/20 0.40
CYP2C19 P33261 1/20 0.40
CASP3 P42574 1/20 0.40
SENP8 Q96LD8 1/20 0.40
SENP7 Q9BQF6 1/20 0.40
SENP6 Q9GZR1 1/20 0.40
LMNA P02545 2/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27901950 0.85 CYP3A4 (0.68) CYP3A4ALDH1A1HSD17B10TSHRKDM4E
SCHEMBL10953230 0.84 CYP3A4 (0.62) CYP3A4ALDH1A1HSD17B10TSHRKDM4E
SCHEMBL9597291 0.82 ACLY (0.53) CYP3A4ALDH1A1HSD17B10KDM4EAGTR1
SCHEMBL7616111 0.81 CYP3A4 (0.51) CYP3A4ALDH1A1HSD17B10TSHRKDM4E
SCHEMBL8957286 0.81 CYP3A4 (0.70) CYP3A4ALDH1A1HSD17B10TSHRKDM4E
SCHEMBL2460812 0.81 CYP3A4 (0.70) CYP3A4ALDH1A1HSD17B10TSHRKDM4E
SCHEMBL1203726 0.81 TSHR (0.61) ALDH1A1HSD17B10TSHRKDM4EKMT2A
SCHEMBL2992712 0.80 AGTR1 (0.49) CYP3A4ALDH1A1HSD17B10KDM4EAGTR1
Bicarbonate SCHEMBL20838538 0.80 CYP3A4 (0.92) CYP3A4ALDH1A1HSD17B10TSHRKDM4E
SCHEMBL1784054 0.79 ALDH1A1 (0.59) CYP3A4ALDH1A1TSHRKDM4EAGTR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0232623-B1 1-CARBACEPHALOSPORIN ANTIBIOTICS ELI LILLY AND COMPANY (US) 1993-03-17 EP disclosed
US-4892942-A 1-CARBA (DETHIA)CEPHALOSPORINS ELI LILLY AND COMPANY (US) 1990-01-09 US disclosed
US-4791106-A 1-Carbacephalosporin antibiotics ELI LILLY AND COMPANY (US) 1988-12-13 US disclosed
EP-0232623-A1 1-Carbacephalosporin antibiotics ELI LILLY AND COMPANY (US) 1987-08-19 EP disclosed