Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.37 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.36 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
| ▸ | TYMS | P04818 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10365902 | 0.88 | ALDH1A1 (0.46) | ALDH1A1GAAKMT2APARP1PARP10 | |
| SCHEMBL10365979 | 0.87 | ALDH1A1 (0.50) | ALDH1A1GAAKMT2APARP1PARP10 | |
| SCHEMBL9602724 | 0.84 | ALDH1A1 (0.46) | ALDH1A1GAAKMT2AMAPK14LMNA | |
| SCHEMBL10367575 | 0.82 | ALDH1A1 (0.48) | ALDH1A1GAAKMT2APARP1PARP10 | |
| SCHEMBL9602782 | 0.81 | HRH3 (0.42) | ALDH1A1GAAKMT2ASMN1; SMN2 | |
| SCHEMBL9602082 | 0.77 | HRH3 (0.45) | ALDH1A1GAAKMT2AMAPK14SMN1; SMN2 | |
| SCHEMBL10366783 | 0.76 | ALDH1A1 (0.49) | ALDH1A1GAAKMT2APARP1PARP10 | |
| SCHEMBL10368024 | 0.76 | ALDH1A1 (0.50) | ALDH1A1GAAKMT2APARP1PARP10 | |
| SCHEMBL9602093 | 0.76 | HRH3 (0.39) | ALDH1A1GAAKMT2AMAPK14 | |
| SCHEMBL9601997 | 0.76 | HRH3 (0.39) | ALDH1A1GAAKMT2ANR3C1MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0351435-B1 | FUSED PYRIDAZINE COMPOUNDS AND THEIR MEDICINAL USES | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1993-08-04 | — | — | EP | disclosed |
| US-5045541-A | Immunodeficiency disorders | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1991-09-03 | — | — | US | disclosed |
| EP-0351435-A1 | FUSED PYRIDAZINE COMPOUNDS AND THEIR MEDICINAL USES | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1990-01-24 | — | — | EP | disclosed |