Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | GAA | P10253 | 4/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | APEX1 | P27695 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 3/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9602497 | 0.84 | ALDH1A1 (0.43) | ALDH1A1GAAKMT2ALMNASMN1; SMN2 | |
| SCHEMBL10365902 | 0.84 | ALDH1A1 (0.46) | ALDH1A1MAPTGAAL3MBTL1KMT2A | |
| SCHEMBL10365979 | 0.84 | ALDH1A1 (0.50) | ALDH1A1MAPTGAAKMT2AMEN1 | |
| SCHEMBL9602782 | 0.84 | HRH3 (0.42) | ALDH1A1MAPTGAAL3MBTL1KMT2A | |
| SCHEMBL9602082 | 0.82 | HRH3 (0.45) | ALDH1A1GAAKMT2ASMN1; SMN2MAPK14 | |
| SCHEMBL9601997 | 0.82 | HRH3 (0.39) | ALDH1A1GAAKMT2AMAPK14HRH3 | |
| SCHEMBL9602093 | 0.82 | HRH3 (0.39) | ALDH1A1GAAKMT2AMEN1MAPK14 | |
| SCHEMBL9865213 | 0.82 | HRH3 (0.37) | ALDH1A1MAPTGAAKMT2AMEN1 | |
| SCHEMBL9601550 | 0.81 | HRH3 (0.40) | ALDH1A1GAAKMT2AMAPK14HRH3 | |
| SCHEMBL9873107 | 0.80 | HRH3 (0.38) | ALDH1A1GAAKMT2AMEN1MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0351435-B1 | FUSED PYRIDAZINE COMPOUNDS AND THEIR MEDICINAL USES | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1993-08-04 | — | — | EP | disclosed |
| US-5045541-A | Immunodeficiency disorders | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1991-09-03 | — | — | US | disclosed |
| EP-0351435-A1 | FUSED PYRIDAZINE COMPOUNDS AND THEIR MEDICINAL USES | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1990-01-24 | — | — | EP | disclosed |