Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 8/20 | 0.67 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.63 |
| ▸ | HTR3A | P46098 | 7/20 | 0.60 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | HTR3B | O95264 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | THPO | P40225 | 1/20 | 0.60 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.60 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.60 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.60 |
| ▸ | DRD2 | P14416 | 1/20 | 0.56 |
| ▸ | DRD3 | P35462 | 1/20 | 0.56 |
| ▸ | HTR7 | P34969 | 1/20 | 0.55 |
| ▸ | HRH1 | P35367 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | DRD4 | P21917 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3679755 | 0.96 | HTR1A (0.65) | HTR1AHRH3HTR3AHTR3EKDM4E | |
| SCHEMBL647772 | 0.84 | HTR1A (0.65) | HTR1AHRH3HTR3AHTR3EKDM4E | |
| SCHEMBL11757164 | 0.81 | HRH3 (0.68) | HTR1AHRH3HTR3AHTR3EKDM4E | |
| SCHEMBL17005644 | 0.80 | HRH3 (0.48) | HTR1AHRH3HTR3ADRD2DRD3 | |
| SCHEMBL3675333 | 0.79 | HTR1A (0.58) | HTR1AHRH3HTR3AHTR3EKDM4E | |
| SCHEMBL3676077 | 0.78 | HTR1A (0.95) | HTR1AHRH3HTR3ADRD2HTR7 | |
| SCHEMBL8896996 | 0.78 | HRH3 (0.72) | HTR1AHRH3HTR3AHTR3EKDM4E | |
| SCHEMBL3970431 | 0.78 | HRH3 (1.00) | HTR1AHRH3HTR3AHTR3EKDM4E | |
| SCHEMBL9600934 | 0.77 | HTR1A (0.69) | HTR1AHRH3HTR3ADRD2DRD3 | |
| SCHEMBL7993335 | 0.77 | HTR1A (0.62) | HTR1AHRH3HTR3ADRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2906221-B1 | UREA AND AMIDE DERIVATIVES OF AMINOALKYLPIPERAZINES AND USE THEREOF | SOUTHERN RES INST (US) | 2019-05-15 | — | — | EP | disclosed |
| US-9969743-B2 | Urea and amide derivatives of aminoalkylpiperazines and use thereof | SOUTHERN RESEARCH INSTITUTE (US) | 2018-05-15 | — | — | US | disclosed |
| US-20170190711-A1 | UREA AND AMIDE DERIVATIVES OF AMINOALKYLPIPERAZINES AND USE THEREOF | SOUTHERN RESEARCH INSTITUTE | 2017-07-06 | — | — | US | disclosed |
| US-9598387-B2 | Urea and amide derivatives of aminoalkylpiperazines and use thereof | SOUTHERN RESEARCH INSTITUTE (US) | 2017-03-21 | — | — | US | disclosed |
| US-20150232435-A1 | UREA AND AMIDE DERIVATIVES OF AMINOALKYLPIPERAZINES AND USE THEREOF | SOUTHERN RESEARCH INSTITUTE (US) | 2015-08-20 | — | — | US | disclosed |
| EP-0309544-B1 | PSYCHOTROPIC BICYCLIC IMIDES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-02-10 | — | — | EP | disclosed |
| EP-0286263-B1 | PSYCHOTROPIC POLYCYCLIC IMIDES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1991-05-15 | — | — | EP | disclosed |
| US-4824999-A | INTERMEDIATES FOR ANTIPSYCHOTIC AND ANXIOLYTIC AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1989-04-25 | — | — | US | disclosed |
| EP-0309544-A1 | PSYCHOTROPIC BICYCLIC IMIDES. | AMERICAN HOME PROD (US) | 1989-04-05 | — | — | EP | disclosed |
| US-4797488-A | N-((4-(PHENYL OR HETEROCYCLIC)PIPERAZIN-1-YL)ALKYL)-1,5-METHANOCYCLOPENT(D)AZEPINE-2,4 -DIONES; ANXIOLYTIC AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1989-01-10 | — | — | US | disclosed |
| EP-0286263-A1 | Psychotropic polycyclic imides | AMERICAN HOME PRODUCTS CORPORATION (US) | 1988-10-12 | — | — | EP | disclosed |
| WO-1988007529-A1 | PSYCHOTROPIC POLYCYCLIC IMIDES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1988-10-06 | — | — | WO | disclosed |
| WO-1988007530-A1 | PSYCHOTROPIC BICYCLIC IMIDES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1988-10-06 | — | — | WO | disclosed |
| US-4748240-A | Psychotropic bicyclic imides | AMERICAN HOME PRODUCTS CORPORATION (US) | 1988-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170190711-A1 | UREA AND AMIDE DERIVATIVES OF AMINOALKYLPIPERAZINES AND USE THEREOF | HTR2C, HTR4, HTR2A | HTR1A 24/4885HRH3 89/4885HTR3A 17/4885 |
| US-20150232435-A1 | UREA AND AMIDE DERIVATIVES OF AMINOALKYLPIPERAZINES AND USE THEREOF | DRD2, CHRM2, NPY2R | HTR1A 82/4885HRH3 358/4885HTR3A 37/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.