Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 8/20 | 0.69 |
| ▸ | DRD2 | P14416 | 2/20 | 0.57 |
| ▸ | DRD3 | P35462 | 2/20 | 0.57 |
| ▸ | HTR3A | P46098 | 9/20 | 0.57 |
| ▸ | HTR7 | P34969 | 1/20 | 0.52 |
| ▸ | HRH1 | P35367 | 1/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9822980 | 0.83 | HTR1A (0.67) | HTR1ADRD2DRD3HTR3AHTR7 | |
| SCHEMBL3676077 | 0.79 | HTR1A (0.95) | HTR1ADRD2HTR3AHTR7HRH3 | |
| SCHEMBL9602546 | 0.77 | HTR1A (0.67) | HTR1ADRD2DRD3HTR3AHTR7 | |
| SCHEMBL647772 | 0.76 | HTR1A (0.65) | HTR1ADRD2DRD3HTR3AHTR7 | |
| SCHEMBL3679755 | 0.76 | HTR1A (0.65) | HTR1ADRD2DRD3HTR3AHTR7 | |
| SCHEMBL9600927 | 0.75 | HTR1A (0.44) | HTR1ADRD2HTR7 | |
| SCHEMBL9586993 | 0.75 | DRD2 (0.73) | HTR1ADRD2 | |
| SCHEMBL7993109 | 0.75 | HTR1A (0.61) | HTR1ADRD2DRD3HTR3AHTR7 | |
| SCHEMBL7993335 | 0.73 | HTR1A (0.62) | HTR1ADRD2DRD3HTR3AHRH3 | |
| SCHEMBL3683967 | 0.73 | HTR3A (0.80) | HTR1AHTR3AHTR7HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0309544-A1 | PSYCHOTROPIC BICYCLIC IMIDES. | AMERICAN HOME PROD (US) | 1989-04-05 | — | — | EP | claimed |
| WO-1988007530-A1 | PSYCHOTROPIC BICYCLIC IMIDES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1988-10-06 | — | — | WO | claimed |
| US-4748240-A | Psychotropic bicyclic imides | AMERICAN HOME PRODUCTS CORPORATION (US) | 1988-05-31 | — | — | US | claimed |
| EP-0309544-B1 | PSYCHOTROPIC BICYCLIC IMIDES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-02-10 | — | — | EP | disclosed |
| US-4748240-A | Psychotropic bicyclic imides | AMERICAN HOME PRODUCTS CORPORATION (US) | 1988-05-31 | — | — | US | disclosed |