Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.72 |
| ▸ | TSHR | P16473 | 2/20 | 0.72 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.72 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.69 |
| ▸ | TP53 | P04637 | 3/20 | 0.69 |
| ▸ | GAA | P10253 | 1/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.67 |
| ▸ | MEN1 | O00255 | 3/20 | 0.67 |
| ▸ | BRD4 | O60885 | 2/20 | 0.57 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.57 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.54 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.51 |
| ▸ | GSK3B | P49841 | 3/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11156685 | 0.85 | ALDH1A1 (0.65) | SMN1; SMN2ALDH1A1TSHRHSD17B10MAPK1 | |
| SCHEMBL9817819 | 0.84 | ALDH1A1 (1.00) | SMN1; SMN2ALDH1A1TSHRHSD17B10MAPK1 | |
| SCHEMBL4116168 | 0.77 | ALDH1A1 (0.69) | SMN1; SMN2ALDH1A1TSHRHSD17B10MAPK1 | |
| SCHEMBL4539804 | 0.76 | SLC2A1 (0.63) | SMN1; SMN2ALDH1A1TSHRMAPK1TP53 | |
| SCHEMBL9271327 | 0.74 | BRD4 (0.54) | SMN1; SMN2ALDH1A1TSHRHSD17B10MAPK1 | |
| SCHEMBL7327312 | 0.74 | HSD17B10 (0.73) | SMN1; SMN2ALDH1A1TSHRHSD17B10MAPK1 | |
| SCHEMBL30520180 | 0.74 | HSD17B10 (0.73) | SMN1; SMN2ALDH1A1TSHRHSD17B10MAPK1 | |
| SCHEMBL8144156 | 0.74 | SLC2A1 (0.52) | SMN1; SMN2ALDH1A1TSHRHSD17B10MAPK1 | |
| SCHEMBL5020108 | 0.74 | HSD17B10 (0.73) | SMN1; SMN2ALDH1A1TSHRHSD17B10MAPK1 | |
| SCHEMBL7348790 | 0.74 | HSD17B10 (0.73) | SMN1; SMN2ALDH1A1TSHRHSD17B10MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5198557-A | PROCESS FOR THE RESOLUTION OF 3-(4-SUBSTITUTED-PHENYL)-GLYCIDIC ACID DERIVATIVES | ZAMBON GROUP S.P.A. (IT) | 1993-03-30 | — | — | US | disclosed |
| EP-0353538-A2 | Process for the preparation of intermediates for the synthesis of diltiazem | ZAMBON GROUP S.p.A. (IT) | 1990-02-07 | — | — | EP | disclosed |