Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FNTA | P49354 | 3/20 | 0.49 |
| ▸ | FNTB | P49356 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | ATM | Q13315 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | CCR6 | P51684 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.41 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27516303 | 0.88 | FNTA (0.39) | FNTAFNTBPOLBALDH1A1GAA | |
| SCHEMBL6791634 | 0.86 | FNTA (0.38) | FNTAFNTBPOLBAKR1C3ALDH1A1 | |
| SCHEMBL6440948 | 0.86 | MEN1 (0.44) | POLBALDH1A1GAAMAPTKMT2A | |
| SCHEMBL1490768 | 0.82 | ALDH1A1 (0.47) | FNTAFNTBALDH1A1MAPTKDM4E | |
| SCHEMBL9231407 | 0.81 | BAZ2B (0.41) | FNTAFNTBPOLBALDH1A1GAA | |
| SCHEMBL5369223 | 0.79 | KDM4E (0.36) | FNTAFNTBPOLBALDH1A1GAA | |
| SCHEMBL6266511 | 0.78 | ALDH1A1 (0.41) | FNTAFNTBPOLBALDH1A1GAA | |
| SCHEMBL9749020 | 0.77 | ALDH1A1 (0.41) | FNTAFNTBPOLBALDH1A1GAA | |
| SCHEMBL2631222 | 0.77 | MAPT (0.42) | POLBALDH1A1GAAMAPTKMT2A | |
| SCHEMBL19714951 | 0.76 | GAA (0.46) | ALDH1A1GAAMAPTHTTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0022762-B1 | INDOLIZINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR THERAPEUTICAL USE | S.A. SANOFI - LABAZ N.V. (BE) | 1981-11-25 | — | — | EP | claimed |
| EP-0022762-A1 | Indolizine derivatives, process for their preparation and their therapeutical use | S.A. SANOFI - LABAZ N.V. (BE) | 1981-01-21 | — | — | EP | claimed |
| US-5182291-A | Angina pectoris, hypotensive, antiarrhythmia, cerebral vascular insufficiency | SANOFI (FR) | 1993-01-26 | — | — | US | disclosed |
| US-5147878-A | Hypotensive, antiarrhythmia agents | SANOFI (FR) | 1992-09-15 | — | — | US | disclosed |
| US-5039700-A | Cardiovascular disorders, antitumor agents | SANOFI (FR) | 1991-08-13 | — | — | US | disclosed |
| EP-0235111-B1 | INDOLIZINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND COMPOSITIONS CONTAINING THEM | SANOFI S.A. (FR) | 1991-04-10 | — | — | EP | disclosed |
| US-4957925-A | HYPOTENSIVE AGENTS, ANTIARRHYTHMIA AGENTS, TREATMENT OF ANGINA | SANOFI (FR) | 1990-09-18 | — | — | US | disclosed |
| EP-0235111-A1 | Indolizine derivatives, process for their preparation and compositions containing them | SANOFI S.A. (FR) | 1987-09-02 | — | — | EP | disclosed |
| US-4400387-A | USEFUL IN VETERINARY MEDICINE FOR TREATMENT OF PSYCHOLOGICAL DISORDERS | S. A. LABAZ-SANOFI N.V. (FR) | 1983-08-23 | — | — | US | disclosed |
| EP-0022762-B1 | INDOLIZINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR THERAPEUTICAL USE | S.A. SANOFI - LABAZ N.V. (BE) | 1981-11-25 | — | — | EP | disclosed |
| EP-0022762-A1 | Indolizine derivatives, process for their preparation and their therapeutical use | S.A. SANOFI - LABAZ N.V. (BE) | 1981-01-21 | — | — | EP | disclosed |