Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | FNTA | P49354 | 2/20 | 0.33 |
| ▸ | FNTB | P49356 | 2/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | EPHB3 | P54753 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27516303 | 0.83 | FNTA (0.39) | ALDH1A1ALOX15KDM4EMAPTNPC1 | |
| SCHEMBL1490768 | 0.82 | ALDH1A1 (0.47) | ALDH1A1ALOX15KDM4EMAPTNPC1 | |
| SCHEMBL5369223 | 0.82 | KDM4E (0.36) | ALDH1A1ALOX15KDM4EMAPTNPC1 | |
| SCHEMBL9231407 | 0.80 | BAZ2B (0.41) | ALDH1A1KDM4EMAPTNPC1RAB9A | |
| SCHEMBL2631222 | 0.80 | MAPT (0.42) | ALDH1A1KDM4EMAPTNPC1HPGD | |
| SCHEMBL7100135 | 0.79 | ALDH1A1 (0.53) | ALDH1A1KDM4EMAPTSMN1; SMN2KMT2A | |
| Hydrochloric Acid SCHEMBL16468136 | 0.78 | KDM4E (0.41) | ALDH1A1KDM4EMAPTNPC1HPGD | |
| SCHEMBL9602766 | 0.77 | FNTA (0.49) | ALDH1A1KDM4EMAPTFNTAFNTB | |
| SCHEMBL6266511 | 0.77 | ALDH1A1 (0.41) | ALDH1A1ALOX15KDM4EMAPTNPC1 | |
| SCHEMBL3261493 | 0.77 | PLA2G2A (0.34) | ALDH1A1ALOX15KDM4EMAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0254584-B1 | AZABICYCLIC COMPOUNDS, PROCESS FOR THEIR PREPARATION, AND THEIR PHARMACEUTICAL USE | BEECHAM GROUP PLC (GB) | 1992-10-07 | — | — | EP | disclosed |
| US-4822795-A | Pharmaceutically useful esters and amides | BEECHAM GROPUP P.L.C. (GB) | 1989-04-18 | — | — | US | disclosed |
| EP-0254584-A2 | Azabicyclic compounds, process for their preparation, and their pharmaceutical use | BEECHAM GROUP PLC (GB) | 1988-01-27 | — | — | EP | disclosed |